硫酸镁佐治小儿毛细支气管炎的疗效观察

Effective Observation of Magnesium Sulfate in Adjuvant Treatment of Children with Capillary Bronchitis

目的观察硫酸镁佐治小儿毛细支气管炎的疗效。方法将240例毛细支气管炎患儿随机分成对照组和治疗组,各120例。对照组采用抗炎、抗病毒、止咳平喘、血管活性药物及支持等治疗,合并细菌感染时加用抗生素;治疗组在对照组的治疗方案基础上加25%硫酸镁(0.1～0.2)mL/kg/次+10%葡萄糖20mL静脉滴注,每12小时1次,共3～5d。比较两组的疗效及主要观察指标。结果治疗组总有效率为95.0%,对照组为78.3%,两组间差异有统计学意义(P<0.05);治疗组的喘憋缓解时间、咳嗽持续时间、住院时间天数均低于对照组,组间差异有统计学意义(P<0.05);患儿在使用硫酸镁治疗期间未出现明显并发症。结论应用硫酸镁佐治小儿毛细支气管炎方法安全,疗效确切,值得在儿科临床推广。

Objective To explore magnesium sulfate in adjuvant treatment of children with capillary bronchitis. Methods All 240 cas- es of capillary bronchitis were randomly divided into control group and treatment group. Control group used anti-inflammatory,antiviral, relieving cough and asthma,vasoactive drugs and support therapy,and antibiotics when bacterial infection. Treatment group were treated based on the 25% magnesium sulfate 0.1-0.2mL/kg/time＋20mL10% glucose intravenously every 12 hours,a total of 3 to 5 days. The efficacy and the main observed indexes of the two groups were compared. Results The total effective rate was 95.0% in treatment group,78.3% in the control group,and the difference between the two groups was significant （P〈0.05）. Asthmatic response duration, cough duration,days of hospitalization of the treatment group were lower than the control group,the difference between the groups was significant （P〈0.05）. Children in the use of magnesium sulfate did not appear significant complications during treatment. Conclusion Magnesium sulfate in adjuvant treatment of children with capillary bronchitis is safe,effective,worth in the pediatric clinic.