乳腺癌术后纤维粘连蛋白、S-CD105、HER2及VEGF的检测意义研究

Study on the significance of determining fibronectin,S-CD105,HER2 and VEGF after breast cancer operation

目的探讨乳腺癌术后纤维粘连蛋白、S-CD105、HER2及VEGF的检测意义。方法选取2005年1月至2011年2月的乳腺癌术后无复发转移的42例患者为对照组,同时选取同期的42例发生复发转移的患者为观察组,后将两组患者的血清纤维粘连蛋白、S-CD105、HER2及VEGF水平进行检测及比较。结果观察组的血清纤维粘连蛋白、S-CD105、HER2及VEGF水平均高于对照组,且转移患者明显高于无转移的患者,(P<0.05或P<0.01)。结论乳腺癌术后纤维粘连蛋白、S-CD105、HER2及VEGF水平的检测对于判断有无复发转移有着积极的作用。

Objective To study the significance of determining fibronectin,S-CD105,HER2 and VEGF after breast cancer operation.Methods 42 patients without recurrence and metastasis after breast cancer operation from January 2005 to February 2011 were selected as control group,and 42 patients with recurrence and metastasis after breast cancer operation at the same time were selected as observation group,then the serum fibronectin,S-CD105,HER2 and VEGF of two groups were detected and compared.Results The serum fibronectin,S-CD105,HER2 and VEGF of observation group were all higher than those of control group,and the levels of patients with metastasis were higher than those only with recurrence,（P0.05 or P0.01）,there were significant differences or very significant differences. Conclusion The detection of fibronectin,S-CD105,HER2 and VEGF after breast cancer operation plays an active role for judging with or without recurrence and metastasis.