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冠状动脉支架置入后冠心病患者hs-CRP和sCD40L的变化及临床意义 被引量:1

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摘要 目的探讨冠心病(CHD)患者经皮冠状动脉介入治疗(PCI)前后可溶性CD40配体(sCD40L),高敏C反应蛋白(hs-CRP)水平的变化及其临床意义。方法选择我院行PCI的患者74例为治疗组,同期进行冠状动脉造影(CAG)患者48例作为对照组,采用酶联免疫法(ELISA)检测两组术前及术后血清sCD40L、hs-CRP水平变化。结果治疗组术前血清hs-CRP显著高于对照组,差异有统计学意义(P<0.05)。PCI术后24hhs-CRP水平明显高于术前和术后lh的水平(均P<0.05);对照组术后hs-CRP水平高于术前,但差异无统计学意义(P>0.05)。治疗组术后4hsCD40L水平明显低于术前(P<0.05),之后逐渐上升,1周时接近术前水平。对照组手术前后sCD40L水平无变化。结论冠状动脉支架置入术后血清hs-CRP升高和sCD40L水平降低是PCI激活了血管局部或全身的炎症反应,临床应于PCI术后应强化对炎症反应的治疗。
出处 《中国现代药物应用》 2011年第22期30-31,共2页 Chinese Journal of Modern Drug Application
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参考文献5

  • 1Salgado Filho Wj, Martinez Filho EE, Hona P, et al. Intracoronary inflammatory markers after percutaneous coronary interventions. Arq Bras Cardiol,2005,85(3) : 180-185.
  • 2Kwaijtaal M, van Diest R Bar Fw, et al. Inflammatory markers predict late cardiac events in patients who are exhausted after percutaneous coronary intervention. Athemselerosis, 2005, 182 ( 2 ) : 341-348.
  • 3王临光,冯小平.不同支架对冠心病患者介入术后炎症因子的影响[J].心脏杂志,2008,20(1):55-57. 被引量:4
  • 4董平栓,怯红晓,杜来景,杨旭明,王绍欣,杨喜山,李志娟,朱继红,王红雷,汪砚雨,王可,赵玉伟,闫鹏.替罗非班对老年急性冠状动脉综合征介入治疗后血清可溶性CD40配体的影响[J].中国介入心脏病学杂志,2009,17(1):20-23. 被引量:4
  • 5Turker S, Guneri S, Akdeniz B, et al. Usefulness of prepmeedural soluble CD40 ligand for predicting restenosis after percutaneous coronary intervention in patients with stable coronary artery disease. Am J Cardiol, 2006,97(2) :198-202.

二级参考文献14

  • 1吴永健,宋光远,杨跃进.冠心病介入治疗中的药物支架(一)[J].中国医疗器械信息,2005,11(2):45-46. 被引量:10
  • 2叶飞,陈绍良,朱中生,张俊杰,林松,周陵,刘玲玲,阚静,段宝祥.老年高危急性冠状动脉综合征患者介入术中应用替罗非班的有效性和安全性[J].中国介入心脏病学杂志,2007,15(2):93-95. 被引量:16
  • 3Bovill EG, Terrin ML, Stump DC, et al. for the TIMI investigators. Hemorrhagic events during therapy with recombinan tissue typeplasminogen activator, heparin and aspirin for acute myrocardial infarction. Ann Intern Med, 1991,115:256-265.
  • 4The PRISM-PLUS study investigators. Inhibition of the platelet glycoprotein Ⅱ b Ⅲ a receptor with tirofiban in unstable angina and non-Q-wave myocardial infarction. N Engl J Med, 1998,338:1488-1497.
  • 5Egbertson MS, chang CT, Duggan ME, et al. Non-peptide fibrino-genres- ceptor antagonist optimization of a tyrosine-template as a mimic for Arg-Gy-Asp. Med Chem,1994, 37:2537-2551.
  • 6Lef kovittz J, Plow EF, Topol EJ. Platelet glycoprotein IIb/ IIIa receptor antagonist trial. Eur Heart J, 1999,1 (suppl E) :182.
  • 7The RESTORE investigators. Effects of platelet glycoprotein II b/ Ⅲ a blockade with irofiban on adverse cardiac events in patents with unstable angina or acute myocardial infarction undergoing coronary angioplasty. Circulation, 1997,96 : 1445-1453.
  • 8Henn V, Slupsky JR, Grafe M,et al. CD401igand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature, 1998, 391:591-594.
  • 9Graf D, Mullar S, Korthauer U, et al. A soluble form of TRAP (CIM0 ligand) is rapidly released after T cell activation. Eur J Immunol, 1995, 25 : 1749-1754.
  • 10Andre P, Nannizzi Alaimo L, Prasad SK, et al. Platelet derived CD40L : the switch hitting player of cardiovascular disease. Circulation, 2002, 106:896-899.

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