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依达拉奉治疗进展性脑梗死观察

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摘要 目的:观察依达拉奉治疗进展性脑梗死疗效。方法:选择急性进展性脑梗死56例,随机分治疗组与对照组,对照组选择常规药物治疗,治疗组在常规药物基础上加依达拉奉30mg静脉静点,1日2次,14天为1疗程。两组治疗前、治疗2周的临床神经功能缺损程度及疗效评分。结果:2周后两组NIHSS评分均有改善,但治疗组明显优于对照组(P<0.05)。结论:依达拉奉治疗进展性脑梗死明显改善临床症状,降低致残率。
出处 《内蒙古中医药》 2011年第24期96-97,共2页 Inner Mongolia Journal of Traditional Chinese Medicine
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参考文献4

  • 1Tanaka M. Pharmacological and Clinical profile of the free radical scavenger edaravone as a neuroprotective agent [J].Nippon Yakuri- gaku Zasshi,2002,119:301.
  • 2Edaravone Acute Infarction Study Group. Effect of a novel free radical scavenger,edaravone (MC1-186),on acute brain infarction.Randomized,placebo-controlled,double-blind study at multicenters [J].Cerebrovasc Dis,2003,15:222.
  • 3丁煜.抗凝药 奥扎格雷钠(Sodium Ozagrel)[J].国外医药(合成药.生化药.制剂分册),1990,11(3):179-180. 被引量:21
  • 4杨政,吴玉林.治疗急性脑梗死的新型脑保护药依达拉奉[J].中国新药杂志,2002,11(12):911-913. 被引量:353

二级参考文献11

  • 1横田慎一 熊毅雄治 内海光朝.A Pharmacokinetic Study of MCI—186,a novel drug for cerebrovascular disease in elderly and young healthy subjects[J].临床药理,1997,28(3):693-702.
  • 2Mizuno A,Umemura K,Nakashima M.Inhibitory effect MCI-186,a free radical scavenger,on cerebral ischemia following rat middle cerebral artery occlusion[J].Gen Pharmacol,1998,30(4)∶575-578.
  • 3Kawai H,Nakai H,Misao S,et al.Effects of a novel free radical scavenger,MCI-186,on ischemic brain damage in the rat distal middle cerebral artery occlusion model[J].J Pharmacol Exp Ther,1997,281(2)∶921-927.
  • 4Tabrizchi R.Edaravone Mitsubishi-Tokyo[J].Curr Opin Investig Drugs,2000,1(3)∶347-454.
  • 5Yamamoto T,Yuki S,Watanabe T,et al.Delayed neuronal death prevented by inhibition of increased hydroxyl radical formation in a transient cerebral ischemia[J].Brain Res,1997,762(12)∶240-242.
  • 6Watanabe T,Egawa M.Effects of an antistroke agent MCI-186 on cerebral arachidonate cascades[J].J Pharmacol Exp Ther,1994,271(3)∶1624-1629.
  • 7Watanabe T,Morita I,Nishi H,et al.Preventive effect of MCI-186 on 15-HPETE induced vascular endothelial cell injury in vitro[J].Prostaglandins Leukotrienes Essent Fatty Acids,1998,33(1)∶81-87.
  • 8Mitsumori K,Sakuragi M,Kitami K,et al.The effect MCI-186 on regional cerebral blood flow in patients with acute cerebral infarction-A sequential SPECT study[J].Ther Res,1998,19(4)∶1333-1345.
  • 9山本美奈子 高松康雄.Pharmacokinetic studies of 3—methyl—1—phenyl—2—pyrazolin—5—one(MCI—186):protein binding and distribution to red blood cell[J].药理と治疗,1997,25(17):1755-1763.
  • 10大友英一 东仪英夫 小暮久也.MCI—186の脑梗死急性期に对する效果[J].Ther Res,1998,19(4):1311-1332.

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