子宫内膜癌p16/MTS1基因失活的研究

Study on p16/MTS1 gene inactivation in carcinoma of endometrium

目的 探讨 p16 /MTS1基因在子宫内膜癌组织的表达及意义。 方法 采用显微切割 聚合酶链反应方法 ,对 2 9例子宫内膜癌组织和癌旁正常组织中 p16 /MTS1基因纯合缺失进行检测。并用Fisher精确检验的方法 ,对p16 /MTS1基因纯合缺失与临床病理关系进行统计分析。结果 2 9例子宫内膜癌组织 ,p16 /MTS1基因纯合缺失率为 2 4.14 %。Ⅰ期纯合缺失率为 2 4.0 0 % ,Ⅱ期纯合缺失率为 3 3 .3 3 %。结论 p16 /MTS1基因纯合缺失与子宫内膜癌的发生有关。

? Objective To probe the expression of p16/MTS1 gene in carcinoma of endometrium.Methods Homozygous deletion of p16/MTS1 gene was examined by micro cut PCR methods in tissues both of and adjacent to tumor from 29 cases of carcinoma of endometrium,The relation with clinicopathology was analysed by Fisher excates.Results 24.14% homozygous deletion of p16/MTS1 gene was found in carcinoma of endometrium.Conclusions There was a relationship between homozygous deletion of p16/MTS1 gene and occurrencs of carcinoma of endometrium. 〔