^(99m)Tc-MIBI肺显像测定非小细胞肺癌P-糖蛋白表达

^(99m)Tc-MIBI lung imaging for detection of P-glycoprotein expression in non small cell lung cancer

目的 研究99mTc MIBI(甲氧基乙丁基异腈 )肺显像定性检测非小细胞肺癌P 糖蛋白 (P GP)及与化疗效果对比。方法 采用二时相平面显像 ,以病灶处99mTc MIBI的潴留指数 (RI)为P GP定性指标 ,RI <0为P GP阳性 ,以WHO标准将疗效分为完全或者部分缓解 (CR、PR)无变化 (NC) ,进展 (PD) ,将P GP定性结果与疗效比较。结果 3 2例非小细胞肺癌中 2 1例 ( 6 5 .6 % )P GP表达阳性 ,化疗有效率为 9.5 % ,11例 ( 3 4.4% )P GP表达阴性 ,化疗有效率为 81.8% ,两组化疗有效率有显著性差异 (P <0 .0 1)。结论 99mTc MIBI肺显像可作为肺癌P GP非组织学测定方法 ,可预测化疗敏感性 ,指导临床治疗。

? Objective To detect the P glycoprotein (P GP) expression in non small cell lung cancer (NSCLC).Methods 99m Tc MIBI imaging was performed on each patient with a two phase protocol in plane graphic mode.Retention indices (RI) of 99m Tc MIBI at tumor sites were calculated and the negative value of RI was defined as P GP positive.According to the criteria proposed by the WHO,the therapeutic response was scored as complete regression (CR),partial regression (PR),no change (NC) and progress disease(PD).P GP expression was compared with the tumor response after 2 courses of chemotherapy.Results 32 patients with NSCLC were included in this study.21 patients were defined as P GP positive (65.6%) and the chemotherapeutic response rate in these patients was 9.5%,11 patients were P GP negative (34.4%) and the chemotherapy response rate was 81.8%.The response rate in patients with negative P GP was much higher than that in patients with positive P GP.Conclusions 99m Tc MIBI lung imaging is a non invasive technique,which may be employed to predict the chemotherapeutic response of patients with lung cancer. 〔