胸腺瘤中p53、Bcl-2蛋白表达及其临床意义

Expressions of p53,Bcl-2 protein in thymomas and their clinical values

目的 研究 p5 3和Bcl 2蛋白在胸腺瘤中表达及其临床意义。 方法 应用免疫组化染色方法观察胸腺瘤中 p5 3、Bcl 2蛋白表达阳性细胞密度和分布。 结果 5 1例胸腺瘤中 41例 p5 3蛋白表达阳性 ( 80 .4% ) ,p5 3表达与胸腺瘤浸润性密切相关 ,2 3例浸润性胸腺瘤中 16例p5 3蛋白高度表达 ,而 2 8例非浸润性胸腺瘤仅 2例高度表达 (P <0 .0 1) ;梭形细胞型胸腺瘤Bcl 2蛋白均为阳性。结论 提示 p5 3表达异常发生于胸腺瘤的早期 ,其表达异常可作为判断胸腺瘤病变性质的指标。梭形细胞型胸腺瘤可能来源于正常胸腺髓质上皮细胞。

? Objective To study the expressions of p53 and Bcl 2 in thymomas and their clinical values.Methods p53 and Bcl 2 protein expressions in 54 thymomas were examined immunohistochemically.Results forty one of the fifty one thymomas were p53 protein posititve.The expression of p53 correlated with the invasion of thymomas,16 cases out of 23 invasive thymomas were high expressors(the p53 positive tumor cells >50%),whereas only 2 cases of 28 noninvasive thymomas were high expressors.Bcl 2 expression was highly associated with the spindle thymomas.Conclusions The high rate of p53 expressions in thymomas (80.4%) suggests that p53 may be implicated in initial stages of tumorigenesis.The expression of p53 protein is a good indicator for the prognosis of thymomas.The spindle thymoma perhaps relates to the medulary epithelial origins from thymus. 〔