培美曲塞联合顺铂治疗非小细胞肺癌临床观察

目的探讨培美曲塞联合顺铂治疗非小细胞肺癌临床效果。方法 2009年1月～2011年1月收治的经一线化疗后复发或进展的晚期非小细胞肺癌52例,分为单药治疗组(24例),单独应用培美曲塞治疗;联合治疗组(28例)应用培美曲噻联合顺铂治疗;观察两组临床疗效。结果两组有效率、疾病控制率比较差异有统计学意义(P<0.05)。结论培美曲塞二钠联合顺铂是治疗二线非小细胞肺癌较好化疗方案,其毒性作用轻微,患者的耐受性良好,能提高患者化疗后的生活质量。

Objective To investigate the effects of thiophene pemetrexed and cisplatin in treatment of non-small cell lung cancer. Methods Fifty-two cases with advanced non-small cell lung cancer from January 2009 to January 2011 admitted by the recurrence or progression after first-line chemotherapy were divided into 24 cases of single-agent treatment alone pemetrexed thiophene treatment; and 28 cases of combined treatment group, thiophene application pemetrexed combined with cisplatin treatment; the clinical efficacy were observated. Results There were significant difference in efficiency, disease control rate of two groups （P〈0.05）. Conclusion Pemetrexed disodium and cisplatin second-line is good chemotherapy method in treatment of non-small cell lung cancer, the toxic effects is mild, patients can well tolerated, can improve the quality of their life after chemotherapy.