蒙药菟儿丝的化学成分研究

Study on Chemical Constituents of Cuscuta chinensis Lam

目的研究蒙药菟儿丝的化学成分。方法采用硅胶、LH-20柱色谱法及制备高效液相色谱法等分离手段,通过运用各种波谱法和标准品对照法鉴定分离所的化合物。结果分离鉴定了10个黄酮类化合物,分别为5,3'-二羟基-3,6,7,4'-四甲氧基黄酮(1),5,3'-二羟基-6,7,4'-三甲氧基黄酮(2),5,7,3'-三羟基-6,4'-二甲氧基黄酮(3),槲皮素(4),金丝桃苷(5),山柰酚(6),5,7,3'-三羟基-4'-甲氧基黄酮(7),木犀草素(8),3-甲氧基-木犀草素-4'-O-β-D-葡萄糖苷(9),木犀草素-7-O-β-D-葡萄糖苷(10)。结论化合物1、2、3、7、9和10为首次该植物中分得。

OBJECTIVE To study the chemical constituents of the aerial parts of Cuscuta chinensis Lam. METHODS The chemical constituents of Cuscuta chinensis Lam were isolated and purified by silica gel, LH -20 column chromatography and preparation HPLC, etc. Their structures were identified by means of spectra comparison with authentic samples. RESULTS Ten compounds were obtained and identified as 5,3＇-dihydroxy-3,6, 7, 4＇-tetramethoxy flavone （ Ⅰ）, 5, 3＇-dihydroxy-6, 7, 4＇-tritermethoxy flavone （ Ⅱ）, 5, 7, 3＇- triterhydroxy -6, 4＇-dimethoxy flavone （Ⅲ）, quercetin （ Ⅳ）, hyperoside （Ⅴ）, kaempferol （ Ⅵ）, 5, 7, 3＇-triter- hydroxy-4＇-methoxy flavone（ Ⅶ）, luteolin （ Ⅷ）, 3- methoxy-chrysoeriol.-4＇-O-β-D- glucoside （ Ⅸ）, and luteolin-7-O-β-D-glncopyranoside（ Ⅹ ）. CONCLUSION Compounds Ⅰ , Ⅱ, Ⅲ, Ⅷ, Ⅸ and Ⅹ are isolated from this plant for the first time .