肾科病人ADRs发生率与血型、性别、年龄等因素的相关性

A Study on the Relationship Between Blood Type,Sex,Age and the Rate of ADRs in Renal Disease Patients

目的：研究肾病患者的药物不良反应（ＡＤＲｓ） 发生率与患者性别、血型、年龄等的相关性。方法：应用药物流行病学的原理和方法，对住院患者的基本情况和用药情况、药物不良反应等进行记录、分析，用统计学方法探讨性别、血型、年龄等因素对ＡＤＲｓ 的影响。结果：Ａ 型、Ｂ 型、Ｏ 型及ＡＢ 型血患者的ＡＤＲｓ 发生率分别为１０－３ ％ 、１４－３ ％ 、１７ ％ 和３２ ％ ，ＡＢ 型与Ａ 型有显著性差异；女性的ＡＤＲｓ 发生率为１９ ％ ， 高于男性患者（１４ ％ ） ；不同年龄组的患者ＡＤＲｓ 发生率有显著差异； 有烟酒嗜好的患者略高于无此嗜好的患者。结论：性别、血型、年龄等因素均影响肾科病人ＡＤＲｓ 的发生率。

OBJECTIVE:To study the relationship between blood type,sex,age and the rate of ADRs in renal disease patients METHODS: Using the principle and method of pharmacoepidemiology ,the general conditions,the use of medicine and the rate of ADRs of in-patients wers recorded and the influence of blood type,sex and age on the rate of ADRs were statistically analyzed RESULTS:The rates of ADRs of patients with blood type A was 10 3%,type B 14 3%,type O 17 0% and type AB 32 0% There was a significent difference between AB and A; the rate of ADRs of women was 19%,which was higher than that of men(14%);There were significent differences between different age groups;rate of ADRs of middle age group was 22%, that of young patients was 21%,teen-ages 10% and old patients 3 5%;The rate in patients who have the habits of smoking or drinking was 20%, which was higher than that of patients without the habits CONCLUSION:It should be noticed that the blood type,sex and age have certin effect on the rate of ADRs in patients with renal diseases,and it also should be careful when middle age and young people take medicine