摘要
目的:观察rhIL-6 对急性白血病原代细胞体外生长的作用。方法:应用MTT、CFU-L及间接免疫荧光法对18 例急性白血病进行观察。结果:IL-6 体外单独应用对急性白血病原代细胞无明显促增殖及诱导分化作用,但与G-CSF联合则常可抑制原代白血病细胞增殖。结论:IL-6 与G-CSF联合用于化疗。
Objective:To study the effects of recombinant interleukin 6 (rhIL 6) on blast cells proliferation.Method:18 patients with acute leukemias were studied by in vitro using MTT,CFU L and indirect immune fluorescence.Result:Interleukin 6 had slight growth proliferation effect on blast cells.IL 6 combined with G CSF often inhibited blast cells growth of acute myeloblastic leukemias in vitro.Conclusion:IL 6 and G CSF used for the restoration of Chemotherapy induced bone marrow inhibition might be safer than that of combinations of IL 6 with other growth factors in the study.
出处
《临床血液学杂志》
2000年第1期29-31,共3页
Journal of Clinical Hematology
关键词
IL-6
白血病细胞
急性
Interleukin 6 Leukemic blast cell,acute