RAFT法制备pH敏感两亲性嵌段聚合物

Preparation of pH-Sensitive Amphiphilic Diblock Copolymer via the RAFT Process

利用酰胺化反应,合成pH敏感性单体甲基丙烯酸二异丙胺基乙酯(DPA)和亲水性单体N-(2-羟丙基)甲基丙烯酰胺(HPMA),并通过可逆加成—断裂链转移聚合(RAFT)制备pH敏感两亲性二嵌段聚合物。结果显示:该聚合物在水溶液和生理盐水中具有较好的pH敏感性能,并能在一定pH范围内的溶液中形成稳定的胶束,有望作为治疗肿瘤的药物载体。

The pH-sensitive monomer 2-Diisopropylaminoethyl methacrylate （DPA） and the hydrophilic monomer N-（2-Hydroxypropyl） methacrylamide （HPMA） are successfully synthesized using the amidation reaction. Then, pH-sensitive amphiphilic diblock copolymer of DPA with HPMA are prepared by reversible addition-fragmentation transfer （RAFT）. The copolymer has superior property of pH-sensitivity in aqueous solution and physiological saline, and could form stable micelles in solution with certain pH range. Therefore, the copolvmer has potential aPPlication in drug carrier for tumor therapy.