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α-氨基-3-羟基-5-甲基异恶唑-4-丙酸受体与癫痫的研究进展 被引量：6

Progress in research of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors and epilepsy
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摘要 α-氨基-3-羟基-5-甲基异恶唑-4-丙酸受体(AMPA受体)是一种谷氨酸受体,由4个对Ca2+具有不同通透性亚单位组成。其表达或结构的变化可引起自发兴奋性突触后电流(sEPSCs)与微小兴奋性突触后电流(mEPSCs)的幅度和频率增加,提高痫性发作的易感性。亚基GluR2表达下降使AMPA受体对Ca2+的通透性增加,可能与兴奋性神经毒性,以及促进癫痫在海马内的转播有关。本文就AMPA受体与癫痫发生机制的研究进展作一综述。
作者 陈凯 孙红斌
机构地区 泸州医学院 四川省医学院科学院四川省人民医院神经内科
出处 《实用医院临床杂志》 2012年第1期151-154,共4页 Practical Journal of Clinical Medicine
关键词 癫痫 AMPA受体 谷氨酸受体 GluR2亚基
分类号 R363.2 [医药卫生—病理学] R742.1 [医药卫生—神经病学与精神病学]
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参考文献22

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共引文献13

同被引文献30

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  • 10刘蕾,任连坤,焦劲松.边缘性脑炎与相关抗体的研究现状[J].中华神经科杂志,2011,44(10):719-721. 被引量：11

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实用医院临床杂志
2012年 第1期

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