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替比培南匹伏酯及其侧链的合成研究进展 被引量：2

Research Progress of Synthesis of Tebipenem Pivoxil and Its Side Chain
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摘要 替比培南匹伏酯是一种新型的培南类口服抗菌药物,临床用于治疗儿童感染的肺炎、中耳炎和鼻窦炎等。介绍了替比培南匹伏酯的药理作用,综述了替比培南匹伏酯及其侧链的合成方法,并对其市场前景作了展望。 Tebipenem pivoxil, a novel oral carbapenem antibacterial drug, is used to treat children infected pneumonia,otitis media and sinusitis,et al. In this paper,the pharmacologic action of tebipenem pivoxil was in troduced,the synthetic methods of tebipenem pivoxil and its side chain were reviewed and the market prospects were discussed.
作者 黄小光 陈矛 朱少璇 王健松 万平
机构地区 广州白云山制药股份有限公司广州白云山制药总厂
出处 《化学与生物工程》 CAS 2011年第12期20-23,共4页 Chemistry & Bioengineering
关键词 替比培南匹伏酯 侧链 合成 抗菌药物 tebipenem pivoxil side chain synthesis ~ antibacterial drug
分类号 TQ463 [化学工程—制药化工]
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参考文献13

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同被引文献9

  • 1ISODA T, YAMAMURA I, TAMAI S, et al. A practical and facile synthesis of azetidine derivatives for oral carbapenem, L - 084[J]. them Pharm Bull, 2006, 54(10): 1408 -1411.
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  • 3HAYASHHI K, HIKI S, KUMAGAI T. Synthesis of azetidine derivatives using 1 -azabicyclo[ 1.1.0] butane[ J]. Heteroey- eles, 2002, 56( 1/2): 433-442.
  • 4ISODA T, TAMAI S, KUMAGAI T. An efficient method for the synthesis of 3 - mercapto - 1 - ( 1,3 - thiazolin - 2 - yl) azeti- dine useful for the pendant moiety of oral earbapenem, L-0841I]. Heteroeyeles,2006, 68(9) :1821 - 1824.
  • 5张文君,吴文芳,冯小龙.新型口服碳青霉烯类抗菌药物—泰吡培南酯[J].河北医药,2010,32(18):2596-2599. 被引量：19
  • 6董耘婷,张永信.碳青霉烯类抗生素的发展与展望[J].上海医药,2011,32(7):316-319. 被引量：21
  • 7黄小光,黄冰娥,朱少璇.替比培南匹伏酯侧链的合成[J].中国新药杂志,2012,21(4):428-430. 被引量：5
  • 8翟雪,隋强,时惠麟.替比培南酯合成路线图解[J].中国医药工业杂志,2012,43(6):503-506. 被引量：6
  • 9邓玲华,李虹影.碳青霉烯类抗生素的特点与应用[J].中国全科医学,2004,7(2):104-105. 被引量：6

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化学与生物工程
2011年 第12期

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