抗凝药物发展的历史及最新进展

Anticoagulants： a review of its history and newly use

抗凝药物是通过影响凝血过程中的某些凝血因子阻止凝血过程的药物，可用于防止血管内栓塞或血栓形成的疾病，预防中风或其他血栓性疾病。对于血管外科医师来说，在新药层出不穷的今天，回顾抗凝药的发展历程、分类、抗凝机制以及了解其最新进展，无疑是十分重要的。本文就抗凝药的历史及应用进展作一综述。

Anticoagulants is the drugs which prevent blood clotting process by affecting coagulation factor. They can be used for prevention of thromboembolic disease and stroke. As we stand on the threshold of a new era of anticoagulants, it is time to take an overview of the different types of anticoagulants and how to use them in the management of some specific conditions, including pregnancy, renal impairment, heparin- induced thrombocytopenia and cancer.