期刊文献+

血浆纤溶系统与脑梗死面积关系的研究 被引量:1

下载PDF
导出
摘要 人体的纤溶系统中,纤溶酶的转化主要依赖于血浆游离的t-PA和PAI的活性。t-PA是由血管内皮细胞合成的一种丝氨酸蛋白酶,能激活纤溶酶原转变为纤溶酶,同时特异性的结合于纤维蛋白凝块上,加强纤溶效应。PAI是t-PA的抑制物,血管内皮细胞、平滑肌细胞与血小板等均能合成PAI。血小板是PAI重要的储存库。
作者 纪蒙 胡文立
出处 《中国实验诊断学》 北大核心 2011年第12期2079-2080,共2页 Chinese Journal of Laboratory Diagnosis
  • 相关文献

参考文献6

  • 1YU W,Kestanian V,Fisher M.Endovascular recanalization of basilar artery occlusion 80 days after symptom onset[J].Stroke,2007,38∶1387.
  • 2脑血管疾病分类及诊断.中华神经外科杂志,1997,.
  • 3Lo EH,Broderick JP,MoskowtzMA.tPA and proteolysis in the neurovascular unit[J].Stroke,2004,35∶354.
  • 4杜小平,李旻,张乐,杨期东,许宏伟.脑梗死患者的胰岛素抵抗与血浆组织型纤溶酶原激活物抑制物-1活性相关性的研究[J].临床神经病学杂志,2004,17(6):403-405. 被引量:6
  • 5Johansson L,Jansson JH,Boman K,et al.Tissue plasminogen activator,plasminogen activator inhibitor-1 complex as risk factors for the development of a first stroke[J].Stroke,2000,31(1):26.
  • 6Zhang ZG,Chopp M,Goussev A,et al.Cerebral microvascular obstruction by fibrin is associated with upregulation of PAI-1 acutely after onset of focal embolic ischemia in rats[J].J Neurosci,1999,19(24):10898.

二级参考文献17

  • 1李光伟,Step.,L.检测人群胰岛素敏感性的一项新指数[J].中华内科杂志,1993,32(10):656-660. 被引量:2125
  • 2王结义,贾海燕.人血浆组织型纤溶酶原激活剂及其抑制物活性的测定[J].中华医学检验杂志,1989,12(3):163-166. 被引量:32
  • 3Kain K, Catto AJ, Grant PJ. Clustering of thrombotic factors with insulin resistanc in South Asian patients with ischaemic stroke[J]. Thromb Haemost,2002,88:950.
  • 4Banfi C,Eriksson P,Giandomenico G,et al.Transcriptional regulation of plasminogen activator inhibitor type-1 gene by insulin:insights into the signaling pathway[J]. Diabetes,2001,50:1522.
  • 5Samad F,Pandey M,Bell PA,et al.Insulin continues to induce plasminogen activator inhibitor -1 gene expression in insulin-resistant mice and adipocytes[J]. Mol Med,2000,6:680.
  • 6Nordt TK, Bode C, Sobel BE. Stimulation in vivo of expression of intro-abdominal adipose tissue plasminogen activator type Ⅰ by proinsulin[J].Diabetologia,2001,44:1121.
  • 7Carmassi F, Morale M, Ferrini L, et al. Local insulin infusion stimulates expression of plasminogen activator inhibitor-1 and tissue-type plasminogen activator in normal subjects[J]. Am J Med, 1999,107:344.
  • 8Bastard JP,Pieroni L. Plasma plasminogen activator inhibitor, insulin resistance and android obesity[J].Biomed Pharmacother, 1999,53:455.
  • 9Morange PE,Alessi MG,Verdier MD, et al.PAI-1 produced EX vivo by human adipose tissue is relevant to PAI-1 blood level arteriosclerosis[J]. Thromb Vascular Biology,1999, 19:1361.
  • 10Festa A, D'Agostino R Jr, Rich SS,et al. Promotor(4G/5G) plasmiogen activator inhibitior-1 genotype and plasminogen activator inhibitor-1 levels in blacks, Hispancs, and non-Hispanic whites:the insulin resistance atherosclerosis study[J].Circulation,2003,107:2422.

共引文献5

同被引文献15

引证文献1

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部