大分子多糖磁共振成像造影剂的合成、表征及性质研究

Synthesis and evaluation of Gd-DTPA-labeled arabinogalactans as potential MRI contrast agents

利用氯乙酸化、酰胺化等方法合成了大分子多糖阿拉伯半乳聚糖修饰的DOTA钆配合物,采用红外光谱测试、13C NMR、元素分析及ICP-AES手段进行了表征,测试其在水中及牛血清白蛋白溶液中的弛豫效率。结果表明,其弛豫效率远远高于目前临床应用的Gd-DOTA与Gd-DTPA,是比较好的潜在的磁共振成像造影剂。

Arabinogalactan derivatives conjugated with gadolinium-1,4,7,10-tetraazacyclododeca ne-N,N′,N″,N-tetraacetic acid（Gd-DOTA） by ethylenediamine（Gd-DOTA-AGCMC6） has been synthesized and characterized by means of Fourier Transform Infrared Spectra（FTIR）,1H nuclear Magnetic Resonance（1H NMR）,and inductively coupled plasma atomic emission spectrometry（ICP-AES）.The T1 relaxivity of Gd-DOTA-AGCMC6 for 7.64 mmol^-1·L·s^-1 in D2O,7.78 mmol^-1·L·s^-1 in 0.725 mmol^-1·L BSA were higher than that of commercial MRI contrast agent（Gd-DOTA） in aqueous solution.The results indicate that the arabinogalactan-bound complexe is a potential contrast agent for MRI.