心理行为干预辅助治疗痴呆并发行为和精神症状

Cognitive-behavioral Intervention for Patients with Behavioral and Psychological Symptoms of Dementia

目的:探讨心理行为干预辅助治疗痴呆并发行为和精神症状(BPSD)的效果。方法:60例BPSD患者随机分为研究组和对照组各30例,均口服利培酮和脑复康药物治疗。研究组同时辅助心理行为干预治疗。包括记忆、文体活动及ADL训练、行为矫正等。于治疗前后采用痴呆病理行为评定量表(BEHAVE-AD)、简易智能状态量表(MMSE)及ADL能力量表(ADL)评定2组患者的痴呆程度、行为症状及ADL。结果:治疗6周后,2组BEHAVE-AD评分均较治疗前有明显下降(P<0.01),2组间比较,研究组下降更明显(P<0.05)。MMSE评分研究组较治疗前及对照组明显提高,ADL评分明显下降(均P<0.05),而对照组治疗前后变化不明显。结论:心理行为干预辅助治疗BPSD患者,可有效改善其认知,提高残存记忆功能和ADL能力。

Objective： To explore the effect of cognitive-behavioral intervention on patients with behavioral and psychological symptoms of dementia （BPSD）. Methods： Sixty patients with BPSD were randomly divided into study group （treated with combination of cognitive-behavioral intervention and risperidone） and control group （treated with risperidone） for six weeks, and curative effectiveness was evaluate by using the BEHAVE-AD, MMSE and ADL scales. Results： The BEHAVE-AD scores in two groups were significantly decreased after 6 weeks as compared with those before treatement. However, reduction of BEHAVE-AD scores was more prominent in study group than that in control group. The scores of MMSE were significantly higher, and those of ADL were significantly lower in study group than in control group. Conclusion： Cognitive-behavioral intervention combined with risperidone has better efficacy in the treatment of BPSD, and it can improve the quality of life and cognitive function in patients.