三阴性乳腺癌的临床病理特点及预后因素分析

Clinicopathological characteristics and prognosis factors of the triple-negative breast cancer

目的总结三阴性乳腺癌的临床病理学特点及其影响预后的因素。方法回顾性分析111例三阴性乳腺癌患者临床病理特点、复发和生存情况以及影响预后的因素。结果 111例三阴性乳腺癌占同期确诊乳腺癌患者人数的9.6%。三阴性乳腺癌患者发病年龄较轻,中位年龄为46.9岁;瘤体较大,肿瘤直径>5 cm的占21.6%(24/111);临床分期以Ⅱ、Ⅲ期为主,其中Ⅱ期59.5%(66/111),Ⅲ期29.7%(33/111)。67例(60.4%)患者伴腋窝淋巴结转移,40例(36.0%)患者出现复发或转移。单因素分析结果显示,肿瘤大小、TNM分期、淋巴结状态对患者的总生存率的影响有统计学意义。Cox多因素分析显示,肿瘤大小和腋窝淋巴结N分期是影响预后的独立危险因素。结论三阴性乳腺癌为一种独特的乳腺癌亚型,发病年龄轻,临床分期较晚,复发转移率高,预后较差。

Objective To analyze the clinicopathological characteristics and prognostic factors of the patients with tri- ple-negative breast cancer （TNBC）. Methods The datas of 111 TNBC patients were retrospectively analyzed. Clinicopathological characteristics, prognostic factors and overall survival were surveyed. Results Of all the breast cancer cases registered in our hospital during this period, 111 TNBC patients accounted for approximately 9.6%. TNBC occurred mostly in young women, with a median age of 46.9 years. The tumor diameter ≥5 cm was in 24 patients （21.6%）. The stage Ⅱ （59.5%） and stage Ⅲ （29.7%） were more common. Patients with the axillary lymph node metastasis accounted for 60.4% （67/111 ）, 40 （36.0%） patients presented metastases or recurrence. Univariate analysis suggested that tumor size, lymph node status and TNM stage were prognostic factors of TNBC. Cox multivariate analysis demonstrated tumor size and lymph node status were independent prognostic factor. Conclusion TNBC was a special subtype of breast cancer with a recurrence and poor prognosis.