桥连的双[噻吩并[2,3-d]嘧啶-4(3H)-酮]的合成

Synthesis of Bridged Bis(thieno[2,3-d]pyrimidin-4(3H)-ones)

2-氨基-4-三氟甲基-5-甲基-噻吩-3-羧酸乙酯（1）与三苯基膦、六氯乙烷及三乙胺反应，以84％的产率得到膦亚胺2-在碳酸钾的催化下，膦亚胺2与芳基异氰酸酯和双官能亲核试剂的串联氮杂Wittig反应制得新型桥连的双[噻吩并[2，3-加嘧啶-4（3H）-酮]3，产率为58％-82％．所有产物结构经IR，1HNMR，MS表征和元素分析确证．

Ethyl 2-amino-4-trifluoromethyl-5-methyl-thiophene-3-carboxylate （1） reacted with triphenyl- phosphine in hexachloroethane and triethylamine to give iminophosphorane 2 in 84% yield. Further aza-Wittig reactions of iminophosphorane 2 with aromatic isocyanate and bifunctional nucleophilic reagents produced novel bridged bis（thieno[2,3-d]pyrimidin-4（3H）-ones） 3 in the presence of catalytic amounts of potassium carbonate in 58%-82% yields. The structures of all products were confirmed by IR, 1H NMR, MS techniques and elemental analysis.