摘要
钯催化的脱羧基烷基化反应是构建碳碳键特别是手性碳的有效手段,其催化活性高,反应条件温和,对映选择性好.近年来该领域取得了长足的进步.介绍了5年来钯催化的脱羧基烷基化反应,主要是钯催化的对映选择性Tsuji反应及其在天然产物合成中的应用.
Palladium catalyzed decarboxylative alkylation is an effective way to construct carbon-carbon bond especially chiral center with high catalytic activity, mild reaction conditions and good enantioselectivity. In recent years, great achievements have been obtained in this field. This paper summarizes palladium catalyzed decarboxylative alkylation and mainly focuses on enantioselective Tsuji reaction and its utility in natural product synthesis in recent 5 years.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2011年第12期2181-2187,共7页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.21172166)
浙江省自然科学基金(No.Y4100783)资助项目
关键词
钯催化
脱羧基
烯丙基化
苄基化
对映选择性
palladium catalysis
decarboxylation
allylation
benzylation
enantioseletivity
