活血利水中药复方对颈动脉粥样硬化患者内皮素和一氧化氮水平的影响

Influence of Compound Chinese Herbal Medicine of Blood-activating and Urine-inducing on Endothelin (ET) and Nitric Oxide (NO) Levels on Patients with Carotid Atherosclerosis

目的:观察活血利水中药复方对颈动脉粥样硬化患者血浆内皮素和一氧化氮水平的影响。方法:将56例入选患者随机分为两组,对照组予口服阿托伐他汀钙片,20mg/d;治疗组在对照组治疗基础上加服活血利水中药复方,每日1剂;两组疗程均为90天,观察并比较两组治疗前后血清NO和ET水平。结果:两组治疗后NO水平较同组治疗前升高(P<0.05),ET水平较同组治疗前降低(P<0.05);与对照组比较,治疗组治疗后NO和ET水平改善程度更明显(P<0.05)。结论:加用活血利水中药复方能进一步改善血管内皮功能。

Objective：To observe the influence of compound Chinese herbal medicine of blood-activating and urine-inducing on serum endothelin （ET） and nitric oxide （NO） levels on patients with carotid atherosclerosis. Method： 56 cases selected were randomly divided into two groups. Atorvastatin calcium pills for oral use were given to the control group, 20 mg/d,while compound Chinese herbal medicine of blood-activating and urine-inducing was added to the control group based on the treatment for the control group. The medication for both gTOUpS lasted for 90 days,and serum NO together with ET levels were observed and compared before and after treatment. Results： NO level after treatment in both groups was higher than that before in the same group （P〈0.05）, ET level to the contrary （P〈0.05）. Compared with the control group,NO and ET level after in the treatment group were improved more significantly （P〈0.05）. Conclusion：Added compound Chinese herbal medicine of blood-activating and urine-inducing could furtherimprove the function ofendangium.