光动力疗法治疗宫颈上皮内瘤样病变研究进展

Research Advance of Photodynamic Therapy in Cervical Intraepithelial Neoplasia

宫颈上皮内瘤样病变(CIN)是成年妇女宫颈的常见病变,目前缺乏安全有效的保守治疗方法。光动力疗法(PDT)是一种以光敏剂、光源以及氧分子相互作用为基础的治疗方法,现有大量文献报道其探索性地应用于CIN的保守治疗。目前已初步证实系统应用光敏剂的PDT对CIN有较理想的效果,而外用光敏剂的PDT疗效文献报道不一,总的不良反应均很少。PDT的疗效与光敏剂种类及浓度、用药距离照光时间、光照强度参数、PDT操作方法、疗效的评价方法等有关,其各种治疗参数有待于进一步探索。

Cervical intraepithelial neoplasia（CIN） ,a common disease of the cervix in the female adults,lacks of safe and effective conservative treatment at present.Photodynamic therapy（PDT） ,as a new choice for CIN,has a promising prospect for CIN because of its effectiveness and safety.The efficacy of PDT is associated with the photosensitizers and their concentrations,the time span between the topical application and the light activation of the photosensitizers,parameters of the illumination,operation methods,evaluation methods of the therapeutic effect,and so on.We should deeply research on PDT to make it more effective in the treatment of CIN.