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输卵管上皮内癌 被引量：2

Tubal Intraepithelial Carcinoma
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摘要 输卵管上皮内癌为隐性癌,在乳腺癌易感基因(BRCA)突变患者中行预防性双附件切除时发现,其病因不明,人群中发病率不详,在BRCA基因突变患者中其发病率为4.4%～8%,且可早期出现腹腔冲洗液细胞学阳性及盆腔种植转移。对于卵巢癌的起源问题,现仍有争议,认为卵巢癌有两种起源方式,其中高分化浆液性癌被认为是起源于输卵管。输卵管上皮内癌多无症状,早期诊断困难,即使行双附件切除后,仍需仔细行全部输卵管病理检查才能发现,所以临床易漏诊。治疗与卵巢癌相同,输卵管上皮内癌会越来越引起人们的重视。 Tubal intraepithelial carcinoma is occult,which can be found in prophylactic salpingo-oophorectomies from women with BRCA mutations.Etilogy and the incidence of population is unknown.The incidence of women with BRCA mutations is 4.4%～8%.Positive peritoneal washings and pelvic implanted metastasis may appeared.The origin of the ovarian cancer has been debated.There are two ways of origin of ovarian cancer.High-grade serous carcinoma has been considered from fallopian.Tubal intraepithelial carcinoma has been diagnosed difficultly because of no early symptoms.Fallopian be required carefully checking after prophylactic salpingo-oophorectomies.Otherwise tubal intraepithelial carcinoma can be missed.Therapy is similar with ovarian cancer.We must attach importance to tubal intraepithelial carcinoma.
作者 赵建国 曲芃芃
机构地区 天津市中心妇产科医院
出处 《国际妇产科学杂志》 CAS 2011年第6期562-565,共4页 Journal of International Obstetrics and Gynecology
关键词 输卵管肿瘤 卵巢肿瘤 基因 BRCA1 基因 BRCA2 Fallopian tube neoplasms Ovarian neoplasms Genes BRCA1 Genes BRCA2
分类号 R737.31 [医药卫生—肿瘤]
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参考文献21

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同被引文献60

  • 1Zheng W,Fadare O.Fallopian tube as main source for ovarian and pelvic (non-endometrial) serous carcinomas[J] .Int J Clin Exp Pathol,2012,5(3):182-186.
  • 2Mehrad M,Ning G,Chen EY,et al.A pathologist' s road map to benign,precancerous,and malignant intraepithelial proliferations in the fallopian tube[J] .Adv Anat Pathol,2010,17(5):293-302.
  • 3Seidman JD,Yemelyanova A,Zaino RJ,et al.The fallopian tube-peritoneal junction:a potential site of carcinogenesis[J] .Int J Gynecol Pathol,2011,30 (1):4-11.
  • 4Anjarwalla S,Rollason TP,Rooney N,et al.Atypical mucinous metaplasia and intraepithelial neoplasia of the female genital tracta case report and review of the literature[J] .Int J Gynecol Cancer,2007,17(5):1147-1150.
  • 5Mikami Y,Kiyokawa T,Sasajima Y,et al.Reappraisal of synchronous and multifocal mucinous lesions of the female genital tract:a close association with gastric metaplasia[J] .Histopathology,2009,54(2):184-191.
  • 6Wong AK,Seidman JD,Barbuto DA,et al.Mucinous metaplasia of the fallopian tube:a diagnostic pitfall mimicking metastasis[J] .Int J Gynecol Pathol,2011,30 (1):36-40.
  • 7Rabban JT,Crawford B,Chen LM,et al.Transitional cell metaplasia of fallopian tube fimbriae:a potential mimic of early tubal carcinoma in risk reduction salpingo-oophorectomies from women with BRCA mutations[J] .Am J Surg Pathol,2009,33(1):111-119.
  • 8Acs G,Pasha T,Zhang PJ.WT1 is differentially expressed in serous,endometrioid,clear cell,and mucinous carcinomas of the peritoneum,fallopian tube,ovary,and endometrium[J] .Int J Gynecol Pathol,2004,23(2):110-118.
  • 9Kaur H,Levinsky E,Colgan TJ.Papillary syncytial metaplasia of fallopian tube endometriosis[J] .Arch Pathol Lab Med,2013,137(1):126-129.
  • 10Seidman JD,Sherman ME,Bell KA,et al.Salpingitis,salpingoliths,and serous tumors of the ovaries:is there a connection[J] ? Int J Gynecol Pathol,2002,21 (2):101-107.

引证文献2

二级引证文献4

国际妇产科学杂志
2011年 第6期

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