可溶性VEGFR-1、PIGF、PP13对子痫前期的预测价值

The Research Between Prediction of Preeclampsia and Vascular Endothelial Growth Factor Receptor-1,Placental Growth Factor,Placenta Protein 13

子痫前期是严重威胁母婴健康的妊娠期疾病,病因复杂且具有多重性。目前临床上多是在患者出现临床症状后才开始进行一系列治疗,但此时母体及胎儿已受到不同程度的损害,往往母儿预后不佳。通过加强围产期监测,早于临床症状出现之前预测疾病的发生,筛查出高危患者,尽早干预,从而改善妊娠结局,具有重要的临床意义。综述可溶性血管内皮生长因子受体1(Sfit-1)、胎盘生长因子(PIGF)和胎盘蛋白13(PP13)在子痫前期预测中的研究进展。

Preeclampsia is a serious threat to maternal and child health during pregnancy,the etiology and pathogenesis of preeclampsia is complex.At present,we treat patient with clinical symptoms,however,maternal and fetus have been already subject to different degrees of damage.It has important clinical significance to predict the occurrence of preeclampsia prior to clinical symptoms appearance,screen out high-risk patients and make early intervention by strengthening the perinatal monitoring.According to reports of multiple centers worldwide,vascular endothelial growth factor receptor-1（Sfit-1） ,placental growth factor（PIGF） and placenta protein 13（PP13） are expected to be used as early effective predictors of preeclampsia.In this paper,we reviewed the progression of studies on prediction of preeclampsia.