索利那新与特拉唑嗪联合应用治疗良性前列腺增生的疗效观察

Observation of curative effects on the use of solifenacin combined with terazosin for treating benign prostatic hyperplasia

目的评价索利那新与特拉唑嗪联合应用治疗良性前列腺增生的疗效。方法未经治疗的42例无严重梗阻症状的良性前列腺增生患者,观察索利那新与特拉唑嗪联合治疗8周效果。结果用药8周后,国际前列腺症状评分、储尿期刺激症状评分、残余尿量、24h排尿次数、尿失禁次数及夜尿次数均较治疗前均明显下降(P<0.05);最大尿流率和24h平均尿量较治疗前均明显上升(P<0.05)。结论索利那新与特拉唑嗪联合应用可较全面地缓解无严重梗阻症状良性前列腺增生患者的症状,有利于患者生活质量的改善。

Objective To explore the effectiveness of combination therapy with solifenacin and terazosin for patients with benign prostatic hyperplasia.Methods Forty-two patients with benign prostatic hyperplasia without serious obstructive symptom were included in the study.All patients were receiving the combination therapy with solifenacin and terazosin for eight weeks.Results After eight weeks of treatment,.the Prostate Symptoms Score（IPSS）,.score on the urinary storage phase symptoms,residual urine volume,number of micturition per 24 h,number of incontinence per 24 h and frequency of enuresis nocturna significantly decreased （P0.05）,while maximum urinary flow rate and 24-hour mean voiding volume significantly increased.（P0.05）.Conclusion Combination therapy with solifenacin and terazosin can well relieve the symptoms of benign prostatic hyperplasia without serious obstruction of urinary tract,which will benefit the quality of life.