自体角膜缘移植对角膜血管新生抑制作用的实验研究

An experimental study of limbal autograft transplantation inhibiting coneal vascularization.

目的 研究早期自体角膜缘移植对碱烧伤后角膜血管新生 (CNV)的影响。方法 2 0只家兔 ,用NaOH建立角膜新生血管动物模型。在伤后 1、3、5、7天进行自体角膜缘移植。结果 角膜上皮愈合时间手术组平均 12 3 8天 ,对照组 19天。CNV程度 :手术组 1～ 2级 15眼占 93 75 % ,对照组 3～ 4级 4眼占 10 0 %。手术组CNV侵入角膜少 ,血管细小 ,管腔内红细胞少。结论 自体角膜缘移植可抑制CNV ,促进角膜上皮的愈合。

Objective This paper studies the clinical significance of the early limbal autograft transplantation on alkaline corneal burn with corneal vascularization (CNV).Methods The animal model was created in eyes of 20 rabbits by NaOH.Transplantation on the first,third,fifth and seventh day after the alkaline corneal burn.Results Day of corneal epithelial healing operative groups was 12.38 and control groups was 19 less corneal vascularization in the operative groups than the control one.Conclusions The limbal autograft transplantation can inhibit corneal vascularization,and accelerate proliferation of corneal epithelial.