补肾法对颈动脉粥样硬化患者血清超敏C反应蛋白及颈动脉粥样斑块的影响

Effect of tonifying kidney method on the high sensitivity C-reactive protein and carotid atheromatous plaque of patients with the carotid atherosclerosis

目的观察补肾法对颈动脉粥样硬化患者血清超敏C反应蛋白(hs-CRP)及颈动脉粥样硬化斑块的影响,并探讨其防治缺血性脑血管病的机制。方法将125例颈动脉粥样硬化患者随机分为2组,对照组61例予阿托伐他汀和肠溶阿司匹林口服,治疗组64例予补肾汤水煎服。均治疗3个月,观察2组患者血清超敏C反应蛋白及颈动脉粥样硬化程度的变化。结果与治疗前比较,2组治疗后颈动脉平均斑块数量、颈动脉管腔直径、斑块积分及血清hs-CRP含量明显降低(P<0.01);与对照组比较,治疗组治疗后颈动脉平均斑块数量、颈动脉管腔直径、斑块积分以及血清hs-CRP含量均显著降低(P<0.05)。结论补肾法可显著降低颈动脉粥样硬化患者血清hs-CRP,发挥抗颈动脉粥样硬化作用。

Objective To observe the effects of tonifying kidney method on carotid atherosclerotic plaques and plasma high sensitive C-reactive protein（hs-CRP） in patients with carotid atherosclerosis.Methods 125 cases of carotid atherosclerosis were divided into two groups randomly,64 cases in the treatment group were treated by Bushen decoction,and 61 cases in the control group were treated by Atorvastatin and enteric coated aspirin.The treatment lasted for three months.The degree of artherosclerosis and the content of hs-CRP in serum of patients were observed before and after treatment.Results Compared with before treatment,the quantity of plaque,diameter of canalis caroticus,the Carotid Atherosclerosis score and the content of hs-CRP in serum were decreased obviously in two groups（P0.01）;compared with control group,the quantity of plaque,an area of plaque and the content of hs-CRP in serum were decreased obviously in treatment groups after treatment（P0.05）.Conclusion Tonifying kidney method can reduce the hs-CRP level to inhibit carotid artherosclerosis through restraining inflammation damage.