参百止咳合剂治疗慢性支气管炎急性发作30例临床观察

Clinical observation of acute exacerbation of chronic bronchitis treated by Shenbai Zhike mixture

目的观察在西医常规治疗基础上应用参百止咳合剂治疗慢性支气管炎急性发作的临床疗效。方法将60例慢性支气管炎急性发作患者随机分为2组,对照组30例予西医常规治疗,治疗组30例在对照组治疗基础上予参百止咳合剂治疗,2组均7 d为1个疗程,治疗2个疗程后观察疗效,进行症状积分及实验室指标血清白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)比较。结果治疗组总有效率90.0%,对照组总有效率80.0%,2组总有效率比较差异有统计学意义(P<0.05),治疗组疗效优于对照组。2组治疗后症状积分均较本组治疗前降低(P<0.05),且治疗组治疗后症状积分低于对照组(P<0.05)。2组治疗后血清IL-8、TNF-α水平均较本组治疗前降低(P<0.05),且治疗组治疗后血清IL-8、TNF-α水平低于对照组(P<0.05)。结论参百止咳合剂治疗慢性支气管炎急性发作疗效确切,值得临床推广。

Objective To investigate the clinical effect of acute exacerbation of chronic bronchitis treated by Shenbai Zhike mixture.Methods 60 patients with acute exacerbation of chronic bronchitis were randomly divided into two groups.Patients in control group received routine western medicine.Patients in treatment group were treated by Shenbai Zhike mixture combined with routine western medicine.The course was seven days in two groups.After two courses the curative effect was observed.Symptoms score,IL-8 and TNF-α were compared for evaluation of clinical effect.Results The total effective rate in treatment group（90.0%） was higher than that in control group（80.0%,P0.05）.The symptoms score after treatment was decreased in compared with that before treatment in two groups（P0.05）.And the symptoms score in treatment group was lower than that in control group after treatment（P0.05）.The levels of IL-8 and TNF-α in treatment group were lower than those in control group after treatment（P0.05）.Conclusion Shenbai cough mixture is effective in treatment of acute exacerbation of chronic bronchitis,is worthy of clinical.