坦索罗辛与硝苯地平辅助治疗急诊肾绞痛患者86例的临床疗效比较

Comparison of clinical effecacy between tansulosoin and nifedipine on adjuvant therapy of renalcolic

目的分析比较坦索罗辛与硝苯地平口服辅助治疗肾绞痛的临床疗效及耐受性。方法 86例输尿管结石致肾绞痛患者随机分为两组,A组常规止痛治疗加用坦索罗辛口服0.4mg 1次/d;B组常规止痛治疗加用硝苯地平10mg3次/d。所有患者被要求饮水2L/d,疗程为4周或至结石排出。观察患者疼痛缓解情况(视觉模拟量表)、结石排出率、生活质量评分以及药物不良反应发生率并作统计分析。结果 A组患者疼痛缓解情况(视觉模拟量表)、结石排出率、生活质量评分均优于B组患者(P<0.05),两组药物不良反应发生率无差别。结论口服坦索罗辛辅助治疗肾绞痛总体效果优于口服硝苯地平,可以减轻患者的绞痛程度、减少止痛药的用量和辅助排石,且临床耐受性好。

Objective To compare the efficacy and the tolerance of tamsulosoin and nifedipine for the adjuvant therapy in patients with renal colic. Methods 86 patients suffered from renal colic with ureteral calculi were randomly divided into 2 groups （43 patients in each group）. Group A received routine therapy adjuncted with tamsulosoin 0.4mg qd and group B received routine therapy adjuncted with nifedipine 10 mg rid. The patients were asked to drink at least 2 liters water a day. Visual analog scale （VAS）, stone clearance rate, quality of life score and the incidence rate of side effects wre statistically analyzed after 4 weeks or af- ter the stone was eliminated. Results In the stone clearance rate was signficenfly increased in group A compared to in group B. Tile incidence rate of side effects has no differences between two groups. Conclusion Tamsulosin is more effective than nifedipine for adjuvant therapy in patients with renal colic. And it has a good clinical tolerance.