视网膜颞上分支静脉阻塞光学相干断层扫描与多焦视网膜电图的观察

Optical coherence tomography and multifocal electroretinogram in superior temporal branch retinal vein occlusion

目的:观察视网膜颞上分支静脉阻塞的光学相干断层扫描和多焦视网膜电图各参数的特征及相关性。方法:随机选择视网膜颞上支静脉阻塞患者30例(30只眼),对侧眼作为正常对照组,分别行光学相干断层扫描(OCT)及多焦视网膜电图(mfERG)检查,OCT用来观察黄斑区视网膜厚度,mfERG分析其一阶反应的P1、N1波各成分特征。结果:OCT显示患眼各个分区的视网膜厚度与对侧眼比较差异有统计学意义(P<0.05);mfERG显示患眼1环、颞上象限、上半侧区域P1波振幅密度,颞上象限、上半侧区域N1波潜伏期与对侧眼比较差异有统计学意义(P<0.05);患眼CSF视网膜厚度与2环的P1波振幅密度呈显著负相关关系(r=-0.691,P=0.02);直径5 mm中心凹周围视网膜平均厚度与3环P1波振幅密度呈显著负相关关系(r=-0.636,P=0.03)。结论:OCT与mfERG相结合能更全面反映视网膜分支静脉阻塞眼功能、厚度及微结构变化。

Objective： To observe the characteristics and correlation of optical coherence tomography（OCT） and muhifocal electroretinogram （mfERG） in superior temporal branch retinal vein occlusion. Methods： 30 eyes of 30 patients with superior temporal branch retinal vein occlusion （BRVO） and contralateral normal eyes underwent OCT and mfERG examination, OCT was used to detect macular retinal thickness, mfERG was used to analyze the first order kernel responses of P1 and N1 wave components. Results： OCT reveals that there were statistical difference in the retinal thickness between disease eyes and contralateral eyes （P〈0.05）; mfERG reveals that there were statistical difference in the amplitude densities of P1 wave at ringl,superior temporal quadrant and superior hemisphere between disease eyes and contralateral eyes, there were statistical difference in the latencies of N1 wave at superior temporal quadrant and superior hemisphere between disease eyes and contralateral eyes（P〈0.05 ）; Central subfield thickness was negatively correlated with amplitude density of P1 wave at ring 2 （r=-0.691, P=0.02）, perifovea thickness was negatively correlated with amplitude density of P1 wave at ring 3 （r=- 0.636, P=0.03）. Conclusion： OCT and mfERG can comprehensively reflect the change of function, thickness and micostructure in BRVO.