新型噻唑基手性离子液体催化肉桂醛合成γ-丁内酯

Synthesis of γ-Butyrolactone from Cinnamaldehyde Catalyzed by New Thiazolium Chiral Ionic Liquids

以L-薄荷醇、氯化亚砜、4-甲基噻唑等为原料,设计合成出一类新型的噻唑基手性离子液体催化剂,并将其用于催化肉桂醛的自身缩合反应生成γ-丁内酯。实验结果表明,在手性离子液体的催化下,主要得到顺式γ-丁内酯产物。对影响反应的各种因素进行了详细的考察,在较佳的条件下,γ-丁内酯的收率为45.8%。考察了离子液体催化剂的循环使用效果,催化剂可重复使用4次,其催化活性基本不变。

The novel thiazolium chiral ionic liquids were synthesized from L-menthol,thionyl chloride and 4-methylthiazole.The new ionic liquids were used for catalyzing the self-condensation of cinnamaldehyde to synthesize γ-butyrolactone.The experiments results showed the main product was trans-butyrolactone.The effect of reaction conditions on the reaction was fully investigated.Under the optimal conditions,the yield of γ-butyrolactone was 45.8%.The recycling efficiency of ionic liquids catalyst was also investigated.The catalyst could be recycled 4 times,and the catalytic activity kept constant.