哌拉西林-舒巴坦治疗普外科细菌性感染141例临床评价

Clinical Study of Piperacillin-sulbactam in the Treatment of the Bacterial Infection in General Surgery(141 Cases)

目的评价哌拉西林-舒巴坦治疗普外科细菌性感染的临床效果和安全性,并探讨其经济学效果。方法选取普外科141例细菌性感染患者,随机分为试验组70例和对照组71例,试验组给予哌拉西林-舒巴坦3.0 g,2/d,对照组同法给予哌拉西林-他唑巴坦,疗程均为5～14 d。比较两组的临床效果,并运用成本-效果分析法分析其经济学效果。结果试验组与对照组痊愈率、总有效率和不良反应发生率比较差异均无统计学意义(P>0.05),但试验组的成本-效果低于对照组(P<0.05)。结论应用哌拉西林-舒巴坦治疗普外科细菌性感染安全、有效、经济。

Objective To evaluate the efficacy,safety,and economic benefit of Piperacillin-sulbactam in the treatment of bacterial infections in general surgery.Methods 141 patients with bacterial infections in the department of general surgery were randomly divided into study group（n=70） and control group（n=71）.The study group was treated with Piperacillin-sulbactam and the control group with Piperacillin-tazobactam.Drugs were administrated twice and at a dosage of 3.0 g once through intravenous infusion for 5 to 14 days respectively.Clinical effects of the two groups were compared,and the costs were evaluated by pharmacoeconomic cost-effectiveness analysis.Results There were no significant differences between the two groups in cure rates,clinical efficacy rates and adverse reaction rates（P0.05）,and the cost-effect of study group was lower than that of control group（P0.05）.Conclusion Piperacillin-sulbactam is safe,effective and economic in the treatment of bacterial infections in general surgery.