糖尿病大鼠肝脏寄生虫感染对肝脏功能的影响

The effect of parasitic infection on liver function in the diabetic rat liver

目的探讨糖尿病大鼠肝脏寄生虫易感性以及对肝脏功能的影响。方法将37只Wistar大鼠随机分为健康对照组、糖尿病模型3月组、6月组,通过一次性注射链脲佐菌素(STZ)诱导糖尿病模型。实验结束后处死大鼠,观察肝表面囊泡中有无绦虫,用全自动生化分析仪测定肝功能。结果糖尿病模型3月组有1只、6月组有7只感染猫泡尾带绦虫;与健康对照组比较,3月组ALT显著升高(P<0.05),6月组ALT、AST显著升高(P<0.05),3月组ALT和AST与6月组比较差异有统计学意义(P<0.05)。结论糖尿病大鼠肝脏寄生虫易感性增加,肝脏寄生虫感染影响肝脏功能。

Objective To study the parasitic susceptibility and the effect of parasitic infection on liver function in the diabetic rat liver. Methods Thirty-seven Wistar rats were randomly divided into a healthy control group and two groups representing a diabetic model of parasitic infection（DM） at 3 months（DM3） and at 6 months（DM6）.Diabetes was induced with a single injection of streptozotocin（STZ）.At the end of the experiment,the rats were sacrificed,they were checked for the presence or lack of tapeworms in cysts on the surface of the liver,and liver function was determined with an automatic biochemical analyzer. Results One rat in the DM3 group and 7 in the DM6 group were infected with Taenia taeniaeformis.Compared to the healthy control group,the DM3 group had a significantly higher ALT level（P0.05） and the DM6 group had markedly higher ALT and AST levels（P0.05）.Differences in the ALT and AST levels in the DM3 group and DM6 group were statistically significant（P0.05）. Conclusion The diabetic rat liver had increased susceptibility to parasites and parasitic infection affected liver function.