MMP-9和TIMP-1及其在肺纤维化中的作用

Brief discussion of the action of MMP-9 and TIMP-1 in pulmonary fibrosis

肺纤维化是一类以弥漫性肺泡炎和肺泡结构紊乱并最终以瘢痕组织取代正常肺组织为特征的疾病。其发生包括早期的肺泡炎阶段和后期的肺纤维化阶段。肺纤维化的发病机理至今尚未清楚。近年来研究发现,基质金属蛋白酶(MMPS)及其抑制剂(TIMPS)与肺纤维化关系密切。本文就MMP-9和TIMP-1与肺纤维化的关系进行了综述。

Pulmonary fibrosis encompasses a heterogeneous group of diseases characterized by diituse alveolar inflam marion, disruption of alveolar structures, and ultimately replacement of the lung parenchyma with scar tissue. This group of diseases features an early stage of alveolar inflammation and late stage of pulmonary fibrosis. The precise mechanisms of pulmonary fibrosis are poorly understood. Previous research has indicated that matrix metalloproteinases （MMPs） and their inhibitors （TIMPs） are closely associated with the development of pulmonary fibrosis. This paper reviews the rela- tionship between MMP-9, TIMP-1, and pulmonary fibrosis.