摘要
目的探讨人类鼻咽癌(NPC)组织中错配修复基因hMLH1的表达及其与临床病理特征的关系。方法采用免疫组化两步法检测132例鼻咽癌组织、50例鼻咽部慢性炎症的黏膜组织中hMLH1的表达。结果鼻咽癌组织中hMLH1的阳性表达率为55.30%,明显低于鼻咽部慢性炎症的黏膜组织中hMLH1的阳性表达率(76.00%,P<0.05),鼻咽癌组织中hMLH1表达与鼻咽癌T、N分期,以及临床分期、远处转移有关(P<0.05);与年龄、性别无关(P>0.05)。结论鼻咽癌组织中hMLH1表达水平明显下调,hMLH1可能成为预测鼻咽癌预后的生物学指标之一。
Objective To explore the expression of mismatch repair gene hMLH1 in tissue of human nasopharyngeal carcinoma（NPC） and its relation to clinical pathological features.Methods Two-step immunohistochemistry was employed to detect the expression of hMLH1 in 132 tissue samples of NPC and 50 mucosa tissue samples of chronic nasopharyngeal inflammation.Results The positive expression rate of hMLH1 in NPC tissue was 55.30%,which was significantly lower than that（76.00%） in mucosa tissue of chronic nasopharyngeal inflammation（P〈0.05）.The expression of hMLH1 in NPC tissue had relationship with T,N staging and clinical staging of NPC as well as the presence of distant metastasis（P〈0.05）,while no relationship with age and gender.Conclusion The expression level of hMLH1 decreases in NPC tissue and hMLH1 may serve as one of biological markers to predict the prognosis of NPC.
出处
《重庆医学》
CAS
CSCD
北大核心
2011年第36期3689-3690,3693,F0003,共4页
Chongqing medicine
基金
广西壮族自治区卫生厅广西医疗卫生重点科研课题资助项目(200967)
