摘要
CD4+CD25+Treg细胞的主要作用表现为免疫无能性和免疫抑制性,是外周免疫耐受形成机制的主要组成部分。其主要作用机制为分泌抑制性细胞因子(IL-10和TGF-β)、表达细胞表面分子(CTLA-4、GITR等)及Foxp3等。支气管哮喘患者外周血CD4+CD25+Treg功能及数量存在异常,这可能是支气管哮喘发病机制之一。糖皮质激素可以通过影响CD4+CD25+Treg的状态起到抑制支气管哮喘气道炎症的作用。
The main function of CD4＋ CD25＋ Treg cells are immunological anergy and inhibition, which is essential to the maintenance of immunological tolerance in the host. CD4＋ CD25＋ Treg cells produce inhibitory cytokines （TGF-13 and IL-10）, express membrane molecules （CTLA-4,GITR,etc） and Foxp3. There are abnormal in function and quantity of CD4＋ CD25＋ Treg cells of peripheral blood from asthmatic patients, which maybe one of the pathogenesis of asthma. Glucocorticoids can inhibit the airway inflamation of asthma by impacting CD4＋ CD25＋ Treg cells.
出处
《中华哮喘杂志（电子版）》
CAS
2011年第6期44-46,共3页
Chinese Journal of Asthma(Electronic Version)
