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慢性疼痛患者静息态脑功能磁共振的默认网络研究 被引量：10

Study of Default-mode Network in fMRI in Patients with Chronic Pain
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摘要 运用静息态功能磁共振成像技术(resting-state fMRI)研究慢性疼痛患者脑默认网络结构.通过选择双侧膝骨性关节炎(knee osteoarthritis,KOA)患者20例和正常志愿者20名,以后扣带回(posterior cingulated cortex,PCC)为种子点,分别进行fMRI扫描,分析配对两组受试者的脑功能连接情况.结果显示相对正常受试者,KOA患者存在异常脑功能连接,主要表现为PCC呈负激活,边缘叶、脑岛呈正激活. The resting-state functional magnetic resonance imaging（resting-state fMRI） was used to study the brain default network structure of chronic pain patients.In this study,20 patients who afflicted bilateral knee osteoarthritis（KOA） and 20 normal volunteers were selected.Based on seed region of posterior cingu-lated cortex（PCC） of default-mode network,fMRI scan was performed to analyze connection of brain function of the two groups.The results suggest that patients with KOA show abnormal brain functional connectivity which mainly manifest the down-regulation in PCC and up-regulation in limbic lobe and insula lobe com-pared with controls.
作者 谢洪武 罗天友 陈日新 方维东 徐放明 宋云娥 吴飞 吕发金
机构地区 重庆医科大学中医药学院 重庆医科大学附属第一医院放射科 江西中医学院附属医院针灸康复科
出处 《生命科学研究》 CAS CSCD 2011年第6期502-506,共5页 Life Science Research
基金 国家973项目(2009CB522902)
关键词 慢性疼痛 膝骨性关节炎 静息态功能磁共振成像 默认网络 constant pain knee osteoarthritis resting state functional magnetic resonance imaging default network
分类号 R445.2 [医药卫生—影像医学与核医学]
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参考文献19

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共引文献365

同被引文献84

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引证文献10

二级引证文献40

生命科学研究
2011年 第6期

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