免疫应答——乙型肝炎病毒治疗中的双刃剑

Immune Response——The Double-edged Sword of the Treatment of Hepatitis B Virus Infection

人体对乙型肝炎病毒(hepatitis B virus,HBV)感染的免疫应答是一个非常复杂的病理过程,一方面免疫反应能有效清除HBV病毒和被病毒感染的肝细胞,对HBV诱发的肝类疾病有较好的治疗作用;另一方面,免疫反应在清除被感染肝细胞的同时,也引起局部炎症反应,从而损伤正常的肝细胞和组织.其中,特异性免疫T细胞及其产生的细胞因子是这一免疫应答过程的重要参与者.侧重总结了在HBV感染治疗中的关键细胞和分子及激活人体免疫应答治疗中的两面性,为调节自身免疫应答治疗HBV,避免应答不当而引发的肝损伤提供理论基础.

Human immune responses to HBV（Hepatitis B virus,HBV） infection are quite complex.During the pathological process,specific T-lymphocytes and cytokines are the main effectors.On the one hand,they can clear virus of HBV and the infected cells,which are helpful for the cure of the hepatic injury.On the other hand,the immune responses ignite local inflammation and the healthy cells of liver would be damaged.The two sides of immune responses and the key cells and molecules in the process are it reviewed,aimed to set basis for the elimination of hepatic injury in the treatment of HBV by the immunotherapy.