肾脏器官衰老机制的研究进展
摘要
器官衰老是连接细胞衰老和生物体整体衰老的桥梁。肾脏是人体中衰老较快的器官之一，表现为功能减退、修复能力下降、易于向病态转化。本文介绍了近年来肾脏衰老机制研究的新进展。
出处
《老年医学与保健》
CAS
2011年第6期324-327,共4页
Geriatrics & Health Care
基金
基金项目：国家自然科学基金（30870920、30270505、30070288）
国家重点基础研究发展计划（973计划）（2011CBA01003、2007BC507403）
国家重大科学研究计划（2011CB964904）项目资助.
参考文献20
-
1Fontana L, Partridge L, Longo VD. Extending healthy life span-from yeast to humans [J]. Science, 2010, 328 (5976): 321-326.
-
2汪杨,白雪源,魏日胞,陈香美,冯哲,洪权,傅博.高糖对人肾小管上皮细胞氧化应激及蛋白质损伤效应的实验研究[J].解放军医学杂志,2008,33(11):1318-1321. 被引量：2
-
3ACohen HY, Miller C, Bitterman KJ, etal. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 de- acetylase [J]. Science, 2004, 305 (5682): 390-392.
-
4van der Horst A, Tertoolen LG, de Vries-Smits LM, et al. FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2 (SIRT1) [J]. JBiolChem, 2004, 279 (28): 28873-28879.
-
5Mostoslavsky R, Chua KF, Lombard DB, et al. Genomic instability and aging-like phenotype in the absence of mamma- lian SIRT6 [J]. Cell, 2006,124 (2): 315-329.
-
6Zhuo L, Fu B, Bai X, et al. NAD blocks high glucose induced mesangial hypertrophy via activation of the sirtuins-AMPK- mTOR pathway [J]. Cell Physiol Biochem, 2011, 27 (6): 681-690.
-
7Bai X, Chen XM, Feng Z, et al. Identification of basolateral membrane targeting signal of human sodium-dependent dicarbo- xylate transporter 3 [J]. J Cell Physiol, 2006, 206 (3): 821-830.
-
8Bai XY, Chen X, Sun AQ, etal. Membrane topology structure of human high affinity, sodium-dependent dicarboxylate trans- porter [J]. FASEBJ, 2007, 21 (10): 2409-2417.
-
9Liu W, Hong Q, Bai XY, et al. High-affinity Na~-dependent dicarboxylate cotransporter promotes cellular senescence by in- hibiting Sirtum 1 [J]. Mech Ageing Dev, 2010, 131 ( 10): 601-613.
-
10Liu W, Hong Q, Bai XY, et al. High-affinity Na+-dependen- dicarboxylate cotransporter promotes cellular senescence by inl hibitmg Sirtum 1 [J]. Mech Ageing Dev, 2010, 131 (10)t 601-613. /.
二级参考文献10
-
1张雷,方南洙,李井春.长期氧化应激导致葡萄糖对小鼠胚胎发育损伤的机制[J].细胞生物学杂志,2006,28(5):661-666. 被引量：3
-
2边帆,葛勤敏,栗明,苏青.高糖对人腹膜间皮细胞氧化应激的影响[J].上海交通大学学报（医学版）,2007,27(6):685-688. 被引量：4
-
3Ha H, Yu MR, Choi YJ, et al. Role o; high glucose-induced nuclear factor-kappaB activation in monocyte chemoattractant protein-1 expression by mesangial cells. J Am Soc Nephrol, 2002, 13(4) : 894.
-
4Kitada M, Koya D, Sugimoto T, et al. Translocation of glomerular p47phox and p67phox by protein kinase C-beta activation is required for oxidative stress in diabetic nephropathy. Diabetes, 2003, 52(10) : 2603.
-
5Lee EA, Seo JY, Jiang Z, et al. Reactive oxygen species mediate high glucose-induced plasminogen activator inhibitor-1 up-regulation in mesangial cells and in diabetic kidney. Kidney Int, 2005, 67 (5): 1762.
-
6Russell JW, Golovoy D, Vincent AM, et al. High glucose-induced oxidative stress and mitochondrial dysfunction in neurons FASEB J, 2002, 16(13): 1738.
-
7Wei YH, Lee HC, Oxidative stress, mitochondrial DNA mutation, and impairment of antioxidant enzymes in aging. Exp Biol Med (Maywood), 2002, 227(9): 671.
-
8Cederberg J, Basu S, Eriksson UJ. Increased rate of lipid peroxidation and protein carbonylation in experimental diabetic pregnancy. Diabetologia, 2001, 44(6): 766.
-
9孙晶娣,陈吉林,赵久阳,尹永红.高糖对人腹膜间皮细胞生成活性氧的影响[J].大连医科大学学报,2008,30(2):123-126. 被引量：1
-
10梁敏,侯凡凡,田建伟,刘俊,张国华,林跃萍,魏冬梅,陈瑗.终末期肾病氧化应激状态的研究[J].解放军医学杂志,2003,28(6):540-541. 被引量：15
共引文献1
-
1金华,王亿平,王东,代明扬,吕勇,胡顺金,刘家生,茅燕萍,魏玲,任克军.清肾颗粒对慢性肾衰竭湿热证患者氧化应激介导的NF-κB信号通路活化的影响[J].时珍国医国药,2017,28(12):2841-2843. 被引量：15
-
1王秀芝,张丽梅,段立平.老年人用药及其药源性疾病的诊断及预防[J].中国疗养医学,2006,15(6):473-474. 被引量：1
-
2陈可冀,宋军.基础医学[J].中华老年医学杂志,1999,18(5):261-263. 被引量：2
-
3胡美云,岳文.禁防老年人用药引起的药源性疾病[J].中国社区医师（医学专业）,2007,9(10):14-14.
-
4赵佳慧,程庆砾,杜婧,刘胜,王小丹,叶平.阿托伐他汀延缓肾脏衰老机制的探讨[J].中华老年多器官疾病杂志,2012,11(12):933-937. 被引量：1
-
5李典耕,孙雪峰,陈香美.肾脏衰老机制的探讨[J].中华老年多器官疾病杂志,2016,15(4):302-306. 被引量：2
-
6王士雯.老年医学[J].中华医学杂志,2002,82(24):1683-1686. 被引量：4
-
7王士雯,谭端军.1995年中国医学科学进展——老年医学[J].中华医学杂志,1995,75(12):768-770.
-
8《第十一届全国老年医学进展学术研讨会》征文通知[J].实用老年医学,2011,25(2):150-150.
-
9刘静,张永梅.老年患者腹膜透析术后并发腹腔感染的护理体会[J].潍坊医学院学报,2006,28(1):63-63.
-
10张英.专家谈人体衰老机制[J].家庭中医药,2006,13(6):41-41.
