期刊文献+

同型半胱氨酸在脑梗死后血管性认知功能障碍老年患者血清中的变化及其意义 被引量:4

Variation and significance of serum homocysteine in elderly patients with cerebral infarction and vascular cognitive impairment
下载PDF
导出
摘要 目的探讨同型半胱氨酸(homocysteine,Hcy)在脑梗死后血管性认知功能障碍老年患者中的变化及其临床意义。方法依据认知功能评定结果及相应的诊断标准将113例脑梗死老年患者分为两组:57例血管性认知障碍(VCI)患者(实验组)和56例认知功能正常患者(对照组)。取患者外周血,分离血清,检测血清Hcy水平,对所得数据进行组间比较。结果实验组血浆Hcy水平明显高于对照组,差异具有统计学意义(P〈0.05)。非条件Logistic回归分析表明,Hcy是脑梗死后血管性认知障碍的独立危险因素。结论血清Hcy可能是脑梗死后血管性认知功能障碍的病理机制之一。 Objective To investigate the variation and significance of serum homocysteine in elderly patients with cerebral infarction and vascular cognitive impairment (vascular cognitive impairment, VCI ). Methods The concentration of serum Hcy in 57 VCI patients (VCI group) and 56 normal elderly people (control group) were evaluated and compared. Results The level of serum Hcy concentration in the VCI group was significantly higher than that of the control group (P〈0.05). Hcy was a independent risk factor for VCI by non-factor Logistic analysis. Conclusion Hcy may play an important role in the pathological mechanism of vascular cognitive impairment.
出处 《老年医学与保健》 CAS 2011年第6期354-356,共3页 Geriatrics & Health Care
关键词 血管性认知障碍 脑梗死 同型半胱氨酸 Vascular cognitive impairment Cerebral infarction Homocysteine Neuropsychologic examination
  • 相关文献

参考文献11

  • 1王小娟,彭卫平,杨艳红,杨桂凤,杨桂芝.血管性认知功能障碍与超敏C反应蛋白、血脂及尿酸的关系[J].老年医学与保健,2010,16(1):36-38. 被引量:5
  • 2Rockwood K, Howard K, MacKnight C, et al. Spectrum of disease in vascular cognitive impairment [J]. Neuroepidemi- ology, 1999, 18 (5): 248-254.
  • 3Bowler JV. The Concept of vascular cognitive impairment [J]. J Neurol Sci, 2002, 203-204: 11-15.
  • 4汤慈美 王新德.神经心理学[M].北京:人民军医出版社,2001.254-270.
  • 5Schafer JH, Glass TA, Bolla KI, et al. Homocysteine and cognitive function in a population-based study of older adults [J]. J AM Geriatr Soc, 2005, 53 (3): 381-388.
  • 6McCully KS. Vascular pathology of homocysteinemia: implic- ations for the pathogenesis ofarteriosolerosis [J]. AmJ Pathol- ogy, 1969, 56 (1): 111-128.
  • 7Siddique MS, Mendelow AD. Surgical treatment of mtracerebral haemorrhage [J]. BrMedBull, 2000, 56 (2): 444-456.
  • 8Seshadri S, Besiser A, Selhub J, et al. Plasma homocysteine as a risk factor for dementia and Alaheimer' s disease [J]. N EnglJMed, 2002, 346 (7): 476-483.
  • 9Vermeer SE, van Dijk El, Koudstaal PJ, et al. Homocysteine, silem brain infarcts, and white matter lesions: The Rotterdam Scan Study [J]. Ann Neurol, 2002, 51 (3): 285-289.
  • 10Sachdev PS, Valenzuela MJ, Brodaty H, et al. Homocysteine as a risk factor for cognitive impairment in stroke patients [J]. Dement Geriatr Cogn Disord, 2003, 15 (3): 155-162.

二级参考文献16

  • 1de Haan EH, Nys GM, Van Zandvoort MJ. Cognitive function following stroke and vascular cognitive impairment. Curr Opin Neurol, 2006,19 (6): 559-564.
  • 2Mesulam MM. From sensation to cognition. Brain, 1998,121: 1013-1052.
  • 3Finke K, Bublak P, Zihl J. Visual spatial and visual pattern working memory: neuropsychological evidence for a differential role of left and right dorsal visual brain. Neuropsychologia, 2006,44 (4): 649-661.
  • 4Middleton FA, Strick PI. Anotomical evidence for cerebellar and basal ganglia involvement in higher cognitive function. Science, 1994,266 (5184): 458-461.
  • 5Berger A, Sadeh M, Tzur G, et al. Task switching after cerebellar damage. Neuropaychology, 2005,19 (3): 362-370.
  • 6Xiang HD, Weng XC, Lin CY, et al. Involvement of the cerebellum in semantic discrimination: an fMRI study. Human Brain Mapping, 2003,18: 208-214.
  • 7Tatemichi TK, Paik M, Bagiella E, et al. Risk of dementia after stroke in a hospitalized cohort: results of a longitudinal study. Neurology, 1994,44 (10): 1885-1891.
  • 8Zinn S, Bosworth HB, Hoenig HM, et al. Executive function deficits in acute stroke. Arch Phys Med Rehabil, 2007,88 (2): 173-180.
  • 9Koseoglu E, Karaman Y. Relations between homocysteine, folate and vitamin B12 in vascular dementia and in Alzheimer disease [J]. Clin Biochem, 2007,40: 859-863.
  • 10Ravaglia G, Forti P, Maioli F, etal Blood inflammatory markers and risk of dementia: The Conselice Study of Brain Aging [J]. Neurobiol Aging, 2006,28: 1810-1820.

共引文献79

同被引文献114

引证文献4

二级引证文献43

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部