同型半胱氨酸在脑梗死后血管性认知功能障碍老年患者血清中的变化及其意义

Variation and significance of serum homocysteine in elderly patients with cerebral infarction and vascular cognitive impairment

目的探讨同型半胱氨酸（homocysteine，Hcy）在脑梗死后血管性认知功能障碍老年患者中的变化及其临床意义。方法依据认知功能评定结果及相应的诊断标准将113例脑梗死老年患者分为两组：57例血管性认知障碍（VCI）患者（实验组）和56例认知功能正常患者（对照组）。取患者外周血，分离血清，检测血清Hcy水平，对所得数据进行组间比较。结果实验组血浆Hcy水平明显高于对照组，差异具有统计学意义（P〈0．05）。非条件Logistic回归分析表明，Hcy是脑梗死后血管性认知障碍的独立危险因素。结论血清Hcy可能是脑梗死后血管性认知功能障碍的病理机制之一。

Objective To investigate the variation and significance of serum homocysteine in elderly patients with cerebral infarction and vascular cognitive impairment （vascular cognitive impairment, VCI ）. Methods The concentration of serum Hcy in 57 VCI patients （VCI group） and 56 normal elderly people （control group） were evaluated and compared. Results The level of serum Hcy concentration in the VCI group was significantly higher than that of the control group （P〈0.05）. Hcy was a independent risk factor for VCI by non-factor Logistic analysis. Conclusion Hcy may play an important role in the pathological mechanism of vascular cognitive impairment.