miRNA与卵巢癌

MiRNA and Ovarian Cancer

卵巢癌是世界上妇科恶性肿瘤患者死亡的主要原因,严重的威胁着女性的健康.目前,临床上还没有早期特异的诊断方法和治疗方法.microRNA（miRNA）是一类对基因有调控功能的内源性非编码小分子RNA,能与靶mRNA完全或者不完全的互补配对,最终导致mRNA降解或翻译抑制,从而对基因转录后水平进行进一步调控.有研究认为,miRNA在卵巢肿瘤细胞的增殖、分化、凋亡、转移等生物学过程中都有着关键性的作用,因此可能成为卵巢癌早期检测、个体化治疗和治疗后疗效监测的有效方法.

Ovarian cancer is the leading cause of death from Gynaecological malignancy in the world. It is a serious threat to women＇s health. Currently, there is no method of early diagnosis and specific treatment in clinical. MicroRNAs（miRNAs） are an abundant class of small noncoding RNAs that function as negative gene reg- ulators. They can completly or ineomptetly paire with the target mRNA, and lead to mRNA degradation or transla- tional repression. In the present study, miRNA can play a key role in ovarian tumor cell proliferation, differentia- tion, apoptosis, metastasis and other biological processes. Therefore, miRNA may be an efeetive way of early detection and individual treatment in ovarian cancer.