微小RNA与卒中

MicroRNAs and stroke

微小RNA（microRNA，miRNA）是由18～25个核苷酸组成的内源性非编码RNA，可通过完全或部分结合到靶基因mRNA互补序列并使之降解或阻止其翻译而发挥基因调控作用。miRNA在缺血性卒中的发病和病理生理学过程中发挥重要作用。文章对miRNA在缺血性卒中病因学和卒中后病理生理学机制中的作用进行了综述，并对miRNA的应用前景进行了展望。

MicroRNAs （miRNAs） are endogelaous non-coding RNAs composed of 18-25 nucleotides, and they may play a role in gene regulation through completely or partially binding to target gene mRNA complementary sequences and make it degrade or prevent its translation, miRNAs play important roles in the onset and pathophysiological processes of ischemic stroke. This article reviews the roles of miRNAs in the etiology of ischemic stroke and patho-physiological mechanisms after stroke, and the potential application of miRNAs is prospected.