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不同粒径单壁碳纳米管颗粒体外细胞毒性比较

Comparison of in vitro Cytotoxicity of Single-Walled Carbon Nanotubes Particles with Different Sizes
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摘要 本文利用MTT(四唑盐)比色法研究了不同长径比单壁碳纳米管(c-SWNTs)对人肺腺癌(A549)细胞毒性作用,结果表明长径比不同的碳纳米管与细胞作用的初期(24 h),颗粒尺寸越大,细胞毒性越强,而随着作用时间的延长(48 h),小尺寸颗粒的毒性作用增强,颗粒尺寸越小细胞毒性越强,且所有尺寸颗粒的毒性呈现较明显的剂量-效应关系,毒性作用随剂量的增大而增强,并推测其可能的毒作用机制。 A549 cellular toxic response with respect to the different sizes of Single-walled carbon nanotubes(SWNTs)was investigated by the method of mitochondrial function(MTT)assay.Results showed larger particles have higher cytoxicity than smaller particles after exposure of 24h,while the cytoxicity damage of the smaller particle was stronger than the larger particles after 48h,and all the sizes of SWNTs has a obvious dose-effect relationship,the cytotoxicity was enhanced with the dose increasing.The Cells cytotoxicity mechanism was speculated.
出处 《化学研究与应用》 CAS CSCD 北大核心 2011年第12期1693-1697,共5页 Chemical Research and Application
基金 首都经济贸易大学研究基金项目(00891162721716) 科研水平提高项目(碳纳米材料的表面化学修饰及表征)资助
关键词 单壁碳纳米管(SWNTs) 细胞毒性 MTT比色法 Single-walled carbon nanotubes(SWNTs) Cytotoxicity MTT assay
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参考文献23

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