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不同粒径单壁碳纳米管颗粒体外细胞毒性比较

Comparison of in vitro Cytotoxicity of Single-Walled Carbon Nanotubes Particles with Different Sizes
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摘要 本文利用MTT(四唑盐)比色法研究了不同长径比单壁碳纳米管(c-SWNTs)对人肺腺癌(A549)细胞毒性作用,结果表明长径比不同的碳纳米管与细胞作用的初期(24 h),颗粒尺寸越大,细胞毒性越强,而随着作用时间的延长(48 h),小尺寸颗粒的毒性作用增强,颗粒尺寸越小细胞毒性越强,且所有尺寸颗粒的毒性呈现较明显的剂量-效应关系,毒性作用随剂量的增大而增强,并推测其可能的毒作用机制。 A549 cellular toxic response with respect to the different sizes of Single-walled carbon nanotubes（SWNTs）was investigated by the method of mitochondrial function（MTT）assay.Results showed larger particles have higher cytoxicity than smaller particles after exposure of 24h,while the cytoxicity damage of the smaller particle was stronger than the larger particles after 48h,and all the sizes of SWNTs has a obvious dose-effect relationship,the cytotoxicity was enhanced with the dose increasing.The Cells cytotoxicity mechanism was speculated.
作者 任冬梅 李铭 董益阳
机构地区 首都经济贸易大学安全与环境工程学院 中国检验检疫科学研究院
出处 《化学研究与应用》 CAS CSCD 北大核心 2011年第12期1693-1697,共5页 Chemical Research and Application
基金 首都经济贸易大学研究基金项目(00891162721716) 科研水平提高项目(碳纳米材料的表面化学修饰及表征)资助
关键词 单壁碳纳米管(SWNTs) 细胞毒性 MTT比色法 Single-walled carbon nanotubes（SWNTs） Cytotoxicity MTT assay
分类号 O612.4 [理学—无机化学]
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参考文献23

  • 1Hamada N, Savada S, Oshiyama A. et al. New one dimen- sional conductors: Graphitic microtubules [ J ]. Phys Rev Lett, 1992,68 (10) : 1579-1581.
  • 2Kiang C H, Goddard W A, Beyers R, et al. Carbon nano- tubes with single layer wails [ J ]. Carbon, 1995,33 ( 7 ) : 903-914.
  • 3Odom T, Huang J, Kim P, et al. Atomic structure and elec- tronic properties of single walled carbon nanotubes [ J ]. Nature, 1998,391:62-64.
  • 4Service R F. Super strong nanotubes show they are smart, too[ J ]. Sc/ence, 1998,281:940-942.
  • 5Ball P. Roll up for the revolution[J]. Nature,2001,414: 142-144.
  • 6Iijima S, Helical microtubules of graphitic carbon [ J ]. Na- ture, 1991,354:56-58.
  • 7潘晖,曹全喜,佟丽英,周晓华.碳纳米管应用研究[J].微纳电子技术,2002,39(9):14-18. 被引量：10
  • 8Julie Muller, Francois Huaux, Nicolas Moreau, et al. Re- spiratory toxicity of multi-wall carbon nanotubes[ J]. Toxi-col Appl Pharmacol,2005 ,207 (3) :221-231.
  • 9D. B. Warheit, B. R. Laurence, K. L. Reed, et al. Compara- tive pulmonary toxicity assessment of single wall carbon nanotube in rats[J]. ToM, col Sci,2004,77 (1) :117-125.
  • 10Wang H F,Liu Y F,Zhao YL,et al. Preparation and bio- distribution of 125I-labeled water-soluble single-wall car- bon nanotubes [ J ]. J Nanosci Nanotech, 2004,4 ( 8 ) : 1- 8.

二级参考文献24

  • 1[1]IIJIMA S. Helical microtubes of graphitic carbon [J] .Nature, 1991, 354: 56.
  • 2[2]WHICK C T, ROBERTSON D H, MINTMIRE J W. Helical and rotational symmetries of nanoscale graphitic tabules [J]. Phys Rev B, 1993-1, 47: 5485.
  • 3[3]DRESSELHAUS M S, DRESSELHAUS G, EKLUND P C. Science of fullerenes and carbon nanotubes [N]. (Academic,San Diego, 1996)
  • 4[4]TANS S T. Nature, 1997, 586: 474.
  • 5[5]MERTEL R, SCHINIDT T, SHEA H R, et al. Single-and multi-wall carbon nanotube field-effect transistor [ J] .Appl Phys Lett, 1998, 73: 2447.
  • 6[6]DEKKER C, TODAY P. Carbon nanotubes as molecular quantum wires [J] . 1999, 52 (5): 22.
  • 7[7]POSTMA H W C, TEEPAN T, YAO Z, et al. Carbon nanotube single-electron transistor at room temperature [J] . Science, 2001, 76: 293.
  • 8[8]BACHTOLD A, HADLEY P, NAKNANISHI T, et al. Logic circuits with carbon nanotube transistors [J]. Science, 2001, 294:1317.
  • 9[9]WEI B Q, VAJTAI R, AJAYAN P M. Reliability and current carrying capacity of carbon nanotubes [ J] . Appl Phys Lett, 2001, 78: 1172.
  • 10[10]COLLINS P G, HERSAM H, ARNOLD A, et al. Current saturation and electrical breakdown in multi-wall carbon nanotubes [J] .Phys Rev Lett, 2001, 86: 3128.

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化学研究与应用
2011年 第12期

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