炎症与癫痫

Inflammation and Epilepsy

炎症是具有血管系统的活体组织对致炎因子所发生的防御为主的反应。癫痫是一种脑部疾病,由癫痫发作所引起的脑内炎性反应是导致癫痫发作后脑组织病理改变,特别是海马结构损伤(包括海马内神经元脱失、神经元凋亡、胶质细胞增生、纤维发芽、海马硬化等)的主要原因之一。现就炎性反应在癫痫发生中的作用及其机制进行综述。

Inflammation is a response, mainly defensive, of living vascular tissue to proinflammatory cytokines. Epilepsy is a brain disease, and the inflammatory response of the brain caused by seizures is one of the main reasons leading to the pathological changes of brain tissues, particularly structural damage in the hippocampus （ including hippocampal neuron loss, neuronal apoptosis, glial cell proliferation, fiber sprouting, hippocampal sclerosis etc. ）. The review focuses on the effects of inflammatory response in the occurrence of epilepsy and its mechanisms.