血清尿酸水平与冠状动脉支架植入术后再狭窄的关系

Relationship between serum uric acid level and intracoronary in-stent restenosis

目的探讨血清尿酸(UA)水平与冠状动脉支架植入后再狭窄的相关性。方法 2005年2月至2010年8月对行冠状动脉支架植入术,并于术后1年行冠状动脉造影随访的患者797例,以支架植入段内径狭窄≥50%为再狭窄,分为再狭窄组(153例)和对照组(644例),回顾性分析两组患者的血清UA及其他临床生化指标的差异。结果再狭窄组的血清UA水平为(406.54±78.18)μmol/L,明显高于对照组(343.78±76.64)μmol/L,且差异有统计学意义(P<0.01)。多因素logistic逐步回归分析显示,高尿酸血症是支架内再狭窄的独立危险因素(OR=1.653)。结论高尿酸血症与冠状动脉支架内再狭窄明显相关,降低血UA浓度可能减少再狭窄的发生。

Objective To assess the correlation between serum uric acid level and intracoronary in-stent restenosis（ISR）. Methods One year′s follow-up of coronary angiography after percutaneous coronary intervention（PCI） was performed in 797 patients with PCI from February in 2005 to August in 2010.ISR was defined as luminal diameter narrowing of intracoronary stent by 50% or greater.According to the results of coronary angiography,797 patients were divided into two groups：restenosis group（153 patients） and control group（644 patients）.The difference of serum uric acid and other clinical biochemical parameters between two groups was analyzed retrospectively. Results The level of serum uric acid was significantly higher in restenosis group than that in control group,and was significantly different with that in control group in statistics,（406.54±78.18） μmol/L vs（343.78±76.64） μmol/L（P〈0.01）.Multivariate logistic regression analysis revealed that hyperuricemia was an independent risk factor of ISO（OR=1.653）. Conclusion Serum higher uric acid level was correlated with ISR.The occurrence of ISR may be reduced by lowering serum concentration of uric acid.