摘要
目的研究甘肃省汉族和回族人非综合征唇腭裂与转化生长因子-α基因多态性的相关性。方法采用聚合酶链反应-限制性酶切片段长度多态性方法 ,对50例汉族非综合征唇腭裂患者与50例正常汉族人,50例回族非综合征唇腭裂患者与50例回族正常人进行TGF-α基因检测分析。结果汉族、回族人非综合征唇腭裂患者的等位基因频率较正常对照组明显增高,差异有统计学意义(P<0.05);汉族和回族人非综合征唇腭裂患者等位基因频率、基因型均差异无统计学意义。结论 TGF-α基因多态性与甘肃省汉族、回族人群非综合症唇腭裂的发生可能有关联,但在汉族和回族患者之间无特异性选择。
Objective To study the association between transforming growth factor a gene (TGF- a) variant and nonsyndromic cleft lip with or without cleft palate (NSCL/P) of Han and Muslin people in Gansu province. Methods TGF-a variant was detected by using RFLP-PCR for DNA samples of the 50 with NSCL/P in Han people and 50 normal people, 50 with NSCL/P in Muslin people and 50 normal people. Results It was found that allele frequency at TGF-a/TaqI locus in NSCL/P groups was significantly higher (P 〈0.05). Conclusion The TGF-a gene polymorphism is related to the occurrence of NSCL/P in Han and Muslin people in Gansu province, but has no particularity between Han and Muslin people with NSCL/P.
出处
《兰州大学学报(医学版)》
CAS
2011年第4期6-9,共4页
Journal of Lanzhou University(Medical Sciences)
基金
兰州大学第一医院青年基金资助项目(2010012)
关键词
非综合症唇腭裂
转化生长因子-Α
基因多态性
等位基因
基因型
nonsyndromic cleft lip with or without cleft palate
transforming growth factoralpha
polymorphism
allele
genotype