急性冠脉综合征患者血清PAPP-A和IL-18的临床表达与相关性分析

Clinical expression of PAPP A and IL-18 and correlation analysis in acute coronary syndrome

目的:观察妊娠相关蛋白酶-A(PAPP-A)和白介素-18(IL-18)在急性冠脉综合征(ACS)中的变化及其相关性。方法:60例经冠状动脉造影证实的冠心病患者,其中稳定性心绞痛组20例、急性心肌梗死组20例、不稳定性心绞痛组20例。另选20例正常健康人为对照组,采用酶联免疫吸附法(ELISA)检测血浆PAPP-A水平。结果:在ACS患者中,血清PAPP-A和IL-18水平明显高于SAP及正常人水平(P<0.01),PAPP-A与IL-18水平呈显著正相关(r2=0.881,P<0.01)。结论:ACS患者PAPP-A、IL-18升高,提示两者均可作为急性冠脉综合征预测预后的新的敏感的标志物。ACS组PAPP-A与IL-18水平呈显著正相关(r2=0.881,P<0.01)。

Objective：To observe the relationship between pregnancy--associated plasma protein-A （PAPP -A） and interleukin -18 （IL-18） in the patients with acute coronary syndrome （ACS）. Methods：Sixty patients with coronary heart disease, who were diagnosed by angiography, were enrolled in this study, In which 20 patients with stable angina, 20 patients with acute myocardial infarction, and 20 patients with unstable angina, and at the same time, randomly selective 20 healthy subjects served as control group. Serum PAPP -A and IL-18 levels were measured by using untrasensitive immunosorbent assay （ELISA）. Results：The plasma levels of PAPP - A and IL-18 were significantly higher in ACS patients than those in SAP and control group （P 〈 0.01）. The significant correlation can be observed between the serum PAPP--A and IL--18 levels in ACS group （r2 = 0. 881,P 〈 0.01）. Conclusion：The plasma levels of PAPP - A and CRP are increased in ACS patients , suggesting the clinical prediction values of both as new sensitive markers in the prognosis of ACS. A significant positive correlation can be observed between the serum PAPP--A and IL-18 levels in ACS group （r2=0. 881,P 〈 0.01）.