我院109例药品不良反应/事件报告分析

Analysis of 109 Case Reports of Adverse Drug Reactions in the Hospital

目的:探讨我院药品不良反应/事件(ADR/ADE)发生的一般规律和特点,为临床合理用药提供参考。方法:收集我院2006～2010年109例报告进行分类统计、分析。结果:报告者比例是医师66.06%,护士11.93%,药师22.02%;新的和严重的ADR/ADE分别是14例(12.84%)、15例(13.76%);静脉滴注给药引起的ADR/ADE为89例占81.65%;涉及药品11个大类65种,其中排序首位的是抗感染药59例(54.13%),有24种药品;皮肤及其附件损害发生率最高,占总病例数的53.21%。结论:应全方位加强ADR/ADE监测工作,以减少和避免药品不良反应发生。

Objective： To discuss adverse drug reaction/events （ADRs/ADEs）occurrence and characteristics of the general laws in hospital, provide a reference for the clinical use of drugs. Methods：To collect the ADR/ADE case reports in our hospital fi＇om 2006 to 2010, and then to class for statistics and analysis on these cases. Result：The proportion of physicians report was 66.06%, 11.93% of nurses, pharmacists 22.02%; new and serious ADR were 14 cases （12.84%）, 15 eases 13.76%;ADR/ADE caused by intravenous administration of 89 eases （81.65%）;involving 65 drugs in 11 categories, including ranking first in the anti-infective 59 cases （54.13%）,24 kinds of drugs; skin and its appendages the highest incidence of damage, 53.21% of the total number of cases. Conclusion：Comprehensive ADR monitoring should be strengthened to reduce and avoid adverse drug reactions.