雷贝拉唑联合奥美拉唑治疗消化性溃疡疗效和安全性评价

The efficacy and safety evaluation omeprazole and fabeprazole treatment of peptic vlcer

目的探讨分析了雷贝拉唑联合奥美拉唑在消化性溃疡治疗过程中的临床疗效以及不良反应。方法 2009年到2011年共收治消化性溃疡患者130例,130例患者随机分为两组,治疗组和对照组,每组患者65例,对照组患者采用口服奥美拉唑进行单独治疗,治疗组患者在对照组治疗的基础上给予雷贝拉唑联合治疗。两组患者在治疗期间均对患者的临床症状以及药物毒副作用进行记录,并分析两组患者治疗的临床有效率。结果治疗组疗效显著性高于对照组,差异具有统计学意义(P<0.05);对照组有4例患者出现头晕以及恶心症状,5例出现腹胀,治疗组3例出现恶心和呕吐以及头晕,4例出现了腹胀,均不影响治疗,均好转,对照组和治疗组患者的不良反应比较差异无统计学意义(P>0.05)。结论雷贝拉唑联合奥美拉唑在治疗消化道溃疡方面具有明显协同效应,其可显著性抑制患者胃酸分泌,清除患者幽门螺杆菌,是临床治疗消化道溃疡较好的药物配伍方案,值得临床推广使用。

Objective To investigate clinical efficacy and adverse reactions of omeprazole rabeprazole in the treatment of peptic ulcer. Methods From 2009to 2011, peptic ulcer were treated in 130 patients, 130 patients randomly divided into treatment group and control group 65 patients in the control group were treated with oral omeprazole for separate treatment, the treatment group in the control group of patients given rabeprazole based combination therapy. Are two groups of patients during treatment of patients with clinical symptoms and medication side effects for recording and analysis of two groups of patients in clinical efficiency. Resuits In control group and treatment group effective clinical treatment of patients, respectively, a significant treatment group Because of the control group, with significant statistical significance （ P 〈 0. 05 ）, the control group, 4 patients had symptoms of dizziness and nausea, 5 patients had abdominal distention, treatment group 3 cases of nausea and vomiting, and dizziness, and 4 there abdominal distension, did not affect the treatment, were improved in the control group and treated group of patients with adverse reactions was no significant differ- ence （P 〉 0. 05）. Conclusion Rabeprazole in the treatment of peptic ulcer combined omeprazole has obvious synergies, which can be significantly inhibited in patients with gastric acid secretion, helicobacter pylori in patients with clear, good clinical treatment of peptic ulcer drug compatibility program, worthy of clinical use.